2y8e

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[[Image:2y8e.png|left|200px]]
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==CRYSTAL STRUCTURE OF D. MELANOGASTER RAB6 GTPASE BOUND TO GMPPNP==
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<StructureSection load='2y8e' size='340' side='right' caption='[[2y8e]], [[Resolution|resolution]] 1.39&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2y8e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y8E OCA]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y8e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y8e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2y8e RCSB], [http://www.ebi.ac.uk/pdbsum/2y8e PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Rab6 is a small GTPase that belongs to the p21 Ras superfamily. It is involved in vesicle trafficking between the Golgi apparatus and endosomes/ER in eukaryotes. The GDP-bound inactive protein undergoes conformational changes when the nucleotide is exchanged to GTP, allowing Rab6 to interact with a variety of different effector proteins. To further understand how these changes affect downstream protein binding, the crystal structure of Rab6 from Drosophila melanogaster has been solved to 1.4 A resolution, the highest resolution for a Rab6 structure to date. The crystals belonged to space group C2, with unit-cell parameters a = 116.5, b = 42.71, c = 86.86 A, alpha = 90, beta = 133.12, gamma = 90 degrees . The model was refined to an R factor of 14.5% and an R(free) of 17.3%.
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Structure of the Drosophila melanogaster Rab6 GTPase at 1.4 A resolution.,Walden M, Jenkins HT, Edwards TA Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Jul 1;67(Pt, 7):744-8. Epub 2011 Jun 23. PMID:21795785<ref>PMID:21795785</ref>
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The line below this paragraph, containing "STRUCTURE_2y8e", creates the "Structure Box" on the page.
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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{{STRUCTURE_2y8e| PDB=2y8e | SCENE= }}
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===CRYSTAL STRUCTURE OF D. MELANOGASTER RAB6 GTPASE BOUND TO GMPPNP===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_21795785}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 21795785 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_21795785}}
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==About this Structure==
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[[2y8e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y8E OCA].
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==Reference==
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<ref group="xtra">PMID:021795785</ref><references group="xtra"/>
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[[Category: Drosophila melanogaster]]
[[Category: Drosophila melanogaster]]
[[Category: Edwards, T A.]]
[[Category: Edwards, T A.]]

Revision as of 07:39, 14 May 2014

CRYSTAL STRUCTURE OF D. MELANOGASTER RAB6 GTPASE BOUND TO GMPPNP

2y8e, resolution 1.39Å

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