3t0l

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'''Unreleased structure'''
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{{STRUCTURE_3t0l| PDB=3t0l | SCENE= }}
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===Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening===
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{{ABSTRACT_PUBMED_23939230}}
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The entry 3t0l is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/1433S_HUMAN 1433S_HUMAN]] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). p53-regulated inhibitor of G2/M progression.
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Authors: Thiel, P., Ottmann, C.
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==About this Structure==
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[[3t0l]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T0L OCA].
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Description: Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening
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==Reference==
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<ref group="xtra">PMID:023939230</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Ottmann, C.]]
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[[Category: Thiel, P.]]
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[[Category: Adapter protein]]
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[[Category: Helical protein]]
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[[Category: Protein binding-inhibitor complex]]
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[[Category: Protein-protein interaction]]

Revision as of 09:03, 4 September 2013

Template:STRUCTURE 3t0l

Contents

Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening

Template:ABSTRACT PUBMED 23939230

Function

[1433S_HUMAN] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). p53-regulated inhibitor of G2/M progression.

About this Structure

3t0l is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Thiel P, Roglin L, Meissner N, Hennig S, Kohlbacher O, Ottmann C. Virtual screening and experimental validation reveal novel small-molecule inhibitors of 14-3-3 protein-protein interactions. Chem Commun (Camb). 2013 Aug 27;49(76):8468-70. doi: 10.1039/c3cc44612c. PMID:23939230 doi:10.1039/c3cc44612c

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