2oxk
From Proteopedia
(Difference between revisions)
(New page: 200px<br /><applet load="2oxk" size="350" color="white" frame="true" align="right" spinBox="true" caption="2oxk, resolution 2.00Å" /> '''Helix Bundle Quatern...) |
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caption="2oxk, resolution 2.00Å" /> | caption="2oxk, resolution 2.00Å" /> | ||
'''Helix Bundle Quaternary Structure from alpha/beta-Peptide Foldamers: GCN4-pLI with beta-residues at b and f heptad positions.'''<br /> | '''Helix Bundle Quaternary Structure from alpha/beta-Peptide Foldamers: GCN4-pLI with beta-residues at b and f heptad positions.'''<br /> | ||
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| - | ==Overview== | ||
| - | The function of a protein generally depends on adoption of a specific, folding pattern, which in turn is determined by the side chain sequence, along the polypeptide backbone. Here we show that the sequence-encoded, structural information in peptides derived from yeast transcriptional, activator GCN4 can be used to prepare hybrid alpha/beta-peptide foldamers, that adopt helix bundle quaternary structures. Crystal structures of two, hybrid alpha/beta-peptides are reported along with detailed structural, comparison to alpha-peptides of analogous side chain sequence. There is, considerable homology between alpha- and alpha/beta-peptides at the level, of helical secondary structure, with modest but significant differences in, the association geometry of helices in the quaternary structure. | ||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
| - | Helix | + | Helix bundle quaternary structure from alpha/beta-peptide foldamers., Horne WS, Price JL, Keck JL, Gellman SH, J Am Chem Soc. 2007 Apr 11;129(14):4178-80. Epub 2007 Mar 16. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17362016 17362016] |
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| - | [[Category: Gellman, S | + | [[Category: Gellman, S H.]] |
| - | [[Category: Horne, W | + | [[Category: Horne, W S.]] |
| - | [[Category: Keck, J | + | [[Category: Keck, J L.]] |
| - | [[Category: Price, J | + | [[Category: Price, J L.]] |
[[Category: FMT]] | [[Category: FMT]] | ||
[[Category: coiled coil]] | [[Category: coiled coil]] | ||
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[[Category: helix bundle]] | [[Category: helix bundle]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:23:43 2008'' |
Revision as of 16:23, 21 February 2008
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Helix Bundle Quaternary Structure from alpha/beta-Peptide Foldamers: GCN4-pLI with beta-residues at b and f heptad positions.
About this Structure
2OXK is a Protein complex structure of sequences from [1] with as ligand. Full crystallographic information is available from OCA.
Reference
Helix bundle quaternary structure from alpha/beta-peptide foldamers., Horne WS, Price JL, Keck JL, Gellman SH, J Am Chem Soc. 2007 Apr 11;129(14):4178-80. Epub 2007 Mar 16. PMID:17362016
Page seeded by OCA on Thu Feb 21 18:23:43 2008
Categories: Protein complex | Gellman, S H. | Horne, W S. | Keck, J L. | Price, J L. | FMT | Coiled coil | Foldamer | Helix bundle
