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Ribonucleotide reductase
From Proteopedia
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| - | {{STRUCTURE_2xo4| PDB=2xo4 | SIZE=400| SCENE= |right|CAPTION=Ribonucleotide from ''E. coli'' | + | {{STRUCTURE_2xo4| PDB=2xo4 | SIZE=400| SCENE= |right|CAPTION=Ribonucleotide from ''E. coli'' large subunit and small subunit peptide, [[2xo4]] }} |
'''Ribonucleotide reductase''' (RNR) catalyzes the formation of deoxyribonucleotides from ribonucleotides. The RNR is a tetramer composed from large (RNR1) and small (RNR2) subunits. Thymidine triphosphate (TTP) is an effector in the reaction. | '''Ribonucleotide reductase''' (RNR) catalyzes the formation of deoxyribonucleotides from ribonucleotides. The RNR is a tetramer composed from large (RNR1) and small (RNR2) subunits. Thymidine triphosphate (TTP) is an effector in the reaction. | ||
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[[1zyz]], [[1zzd]], [[2cvs]], [[2cvt]], [[2cvu]], [[2cvv]], [[2cvw]], [[2cvx]], [[2cvy]] - yRNR R1 – yeast<BR /> | [[1zyz]], [[1zzd]], [[2cvs]], [[2cvt]], [[2cvu]], [[2cvv]], [[2cvw]], [[2cvx]], [[2cvy]] - yRNR R1 – yeast<BR /> | ||
| - | [[1pem]] - StRNR R1 - Salmonella typhimurium<BR /> | + | [[1pem]] - StRNR R1 - ''Salmonella typhimurium''<BR /> |
| - | [[5r1r]], [[6r1r]], [[7r1r]], [[1r1r]], [[1rlr]], [[1mrr]] - EcRNR R1 – Escherichia coli | + | [[5r1r]], [[6r1r]], [[7r1r]], [[1r1r]], [[1rlr]], [[1mrr]] - EcRNR R1 – ''Escherichia coli'' |
===RNR large subunit complex=== | ===RNR large subunit complex=== | ||
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[[1yfd]], [[1piz]], [[1pj0]], [[1pj1]], [[1pm2]], [[1pim]], [[1piu]], [[1biq]], [[2av8]], [[1pfr]] - EcRNR R2 (mutant) <BR /> | [[1yfd]], [[1piz]], [[1pj0]], [[1pj1]], [[1pm2]], [[1pim]], [[1piu]], [[1biq]], [[2av8]], [[1pfr]] - EcRNR R2 (mutant) <BR /> | ||
[[3hf1]], [[2vux]], [[2uw2]] – hRNR M2<BR /> | [[3hf1]], [[2vux]], [[2uw2]] – hRNR M2<BR /> | ||
| - | [[3mjo]], [[3dhz]], [[1oqu]], [[1kgn]], [[1kgo]], [[1kgp]] – RNR R2 – Corynebacterium ammoniagenes<BR /> | + | [[3mjo]], [[3dhz]], [[1oqu]], [[1kgn]], [[1kgo]], [[1kgp]] – RNR R2 – ''Corynebacterium ammoniagenes''<BR /> |
| - | [[2p1i]] – RNR R2 – Plasmodium yoelii<BR /> | + | [[2p1i]] – RNR R2 – ''Plasmodium yoelii''<BR /> |
| - | [[2o1z]] - RNR R2 – Plasmodium vivax<BR /> | + | [[2o1z]] - RNR R2 – ''Plasmodium vivax''<BR /> |
[[1w68]], [[1h0n]], [[1h0o]], [[1xsm]] – mRNR R2 – mouse<BR /> | [[1w68]], [[1h0n]], [[1h0o]], [[1xsm]] – mRNR R2 – mouse<BR /> | ||
[[1smq]], [[1sms]] – yRNR 2<BR /> | [[1smq]], [[1sms]] – yRNR 2<BR /> | ||
| - | [[1syy]] - CtRNR R2 – Chlamydia trachomatis<BR /> | + | [[1syy]] - CtRNR R2 – ''Chlamydia trachomatis''<BR /> |
[[2ani]] - CtRNR R2 (mutant) <BR /> | [[2ani]] - CtRNR R2 (mutant) <BR /> | ||
| - | [[1uz]]r – RNR R2 – Mycobacterium tuberculosis<BR /> | + | [[1uz]]r – RNR R2 – ''Mycobacterium tuberculosis''<BR /> |
[[1r2f]] - StRNR R2 | [[1r2f]] - StRNR R2 | ||
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===RNR small+large subunit=== | ===RNR small+large subunit=== | ||
| - | [[ | + | [[2xak]], [[2xap]], [[2xo4]], [[2xo5]] - EcRNR R1+ R2 peptide<BR /> |
| - | [[ | + | |
[[2xav]], [[2xaw]], [[2xax]], [[2xay]], [[2xaz]], [[2x0x]] - EcRNR R1 (mutant) + R2 peptide<BR /> | [[2xav]], [[2xaw]], [[2xax]], [[2xay]], [[2xaz]], [[2x0x]] - EcRNR R1 (mutant) + R2 peptide<BR /> | ||
[[2bq1]] - StRNR R1+ R2 | [[2bq1]] - StRNR R1+ R2 | ||
| - | [[1xjf]] – TmRNR + ATP – Thermotoga maritima<BR /> | + | [[1xjf]] – TmRNR + ATP – ''Thermotoga maritima''<BR /> |
[[1xjg]] - TmRNR + ATP-UDP<BR /> | [[1xjg]] - TmRNR + ATP-UDP<BR /> | ||
[[1xjj]] - TmRNR + GTP<BR /> | [[1xjj]] - TmRNR + GTP<BR /> | ||
Revision as of 07:53, 14 August 2011
Ribonucleotide reductase (RNR) catalyzes the formation of deoxyribonucleotides from ribonucleotides. The RNR is a tetramer composed from large (RNR1) and small (RNR2) subunits. Thymidine triphosphate (TTP) is an effector in the reaction.
Contents |
3D Structures of Ribonucletide reductase
RNR large subunit
1zyz, 1zzd, 2cvs, 2cvt, 2cvu, 2cvv, 2cvw, 2cvx, 2cvy - yRNR R1 – yeast
1pem - StRNR R1 - Salmonella typhimurium
5r1r, 6r1r, 7r1r, 1r1r, 1rlr, 1mrr - EcRNR R1 – Escherichia coli
RNR large subunit complex
3hnc – hRNR M1 + TTP – human
3hnd – hRNR M1 + GDP + TTP
3hne, [[3hnf – hRNR M1 + ATP + TTP
2wgh - hRNR M1 + ATP + Mg
3paw - yRNR R1 + ATP
3k8t - yRNR R1 + ADP analog
2zlf, 2zlg - yRNR R1 + peptide
2eud - yRNR R1 + ligand
1peo, 1peq, 2peu - StRNR R1 + effector
2r1r - EcRNR R1 + TTP
3r1r - EcRNR R1 + AMPPNP
4r1r - EcRNR R1 + GDP + TTP
RNR small subunit
2xof, 3n37, 3n38, 2alx, 1piy, 1r65, 1mxr, 1jqc, 1jpr, 1av8, 1xik, 1rib – EcRNR R2
1yfd, 1piz, 1pj0, 1pj1, 1pm2, 1pim, 1piu, 1biq, 2av8, 1pfr - EcRNR R2 (mutant)
3hf1, 2vux, 2uw2 – hRNR M2
3mjo, 3dhz, 1oqu, 1kgn, 1kgo, 1kgp – RNR R2 – Corynebacterium ammoniagenes
2p1i – RNR R2 – Plasmodium yoelii
2o1z - RNR R2 – Plasmodium vivax
1w68, 1h0n, 1h0o, 1xsm – mRNR R2 – mouse
1smq, 1sms – yRNR 2
1syy - CtRNR R2 – Chlamydia trachomatis
2ani - CtRNR R2 (mutant)
1uzr – RNR R2 – Mycobacterium tuberculosis
1r2f - StRNR R2
RNR small subunit complex
1rsr, 1rsv - EcRNR R2 (mutant) + N3
3n39, 3n3a, 3n3b – EcRNR R2 + NrdI
1rnr – EcRNR R2 (mutant) + dopa
1w69 – mRNR R2 + acetate
RNR small+large subunit
2xak, 2xap, 2xo4, 2xo5 - EcRNR R1+ R2 peptide
2xav, 2xaw, 2xax, 2xay, 2xaz, 2x0x - EcRNR R1 (mutant) + R2 peptide
2bq1 - StRNR R1+ R2
1xjf – TmRNR + ATP – Thermotoga maritima
1xjg - TmRNR + ATP-UDP
1xjj - TmRNR + GTP
1xjk - TmRNR + GTP-ADP
1xjm - TmRNR + TTP
1xje - TmRNR + TTP-GDP
1xjn - TmRNR + ATP-CDP
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky
