2cnw
From Proteopedia
(New page: 200px<br /> <applet load="2cnw" size="450" color="white" frame="true" align="right" spinBox="true" caption="2cnw, resolution 2.39Å" /> '''GDPALF4 COMPLEX OF ...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2CNW is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Thermus_aquaticus Thermus aquaticus]] with MG, ALF, GDP and 5GP as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2CNW OCA]]. | + | 2CNW is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Thermus_aquaticus Thermus aquaticus]] with MG, ALF, GDP and 5GP as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2CNW OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: srp]] | [[Category: srp]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 08:25:33 2007'' |
Revision as of 06:20, 30 October 2007
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GDPALF4 COMPLEX OF THE SRP GTPASES FFH AND FTSY
Overview
The signal recognition particle (SRP) GTPases Ffh and FtsY play a central, role in co-translational targeting of proteins, assembling in a, GTP-dependent manner to generate the SRP targeting complex at the, membrane. A suite of residues in FtsY have been identified that are, essential for the hydrolysis of GTP that accompanies disengagement. We, have argued previously on structural grounds that this region mediates, interactions that serve to activate the complex for disengagement and term, it the activation region. We report here the structure of a complex of the, SRP GTPases formed in the presence of GDP:AlF4. This complex accommodates, the putative transition-state analog without undergoing significant change, from the structure of the ground-state complex formed in the presence of, ... [(full description)]
About this Structure
2CNW is a [Protein complex] structure of sequences from [Thermus aquaticus] with MG, ALF, GDP and 5GP as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Structure of a GDP:AlF4 complex of the SRP GTPases Ffh and FtsY, and identification of a peripheral nucleotide interaction site., Focia PJ, Gawronski-Salerno J, Coon JS 5th, Freymann DM, J Mol Biol. 2006 Jul 14;360(3):631-43. Epub 2006 May 26. PMID:16780874
Page seeded by OCA on Tue Oct 30 08:25:33 2007
Categories: Protein complex | Thermus aquaticus | Focia, P.J. | Freymann, D.M. | Gawronski-Salerno, J. | V, J.S.Coon. | 5GP | ALF | GDP | MG | Cell cycle | Cell division | Cell division/complex | Ffh | Ftsy | Gdp- aluminum fluoride | Gtp-binding | Gtpase | Inner membrane | Membrane | Membrane targeting | Nucleotide-binding | Rna-binding | Signal recognition | Signal recognition particle | Signal sequence recognition | Srp
