361d

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(New page: 200px<br /><applet load="361d" size="350" color="white" frame="true" align="right" spinBox="true" caption="361d, resolution 3.000&Aring;" /> '''CRYSTAL STRUCTURE O...)
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==Overview==
==Overview==
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The synthetic RNA fragment 5'-CUGGGCGG(GCGA)CCGCCUGG (nucleotides in, parentheses indicate the loop region) corresponds to the natural sequence, of domain E from nucleotides 79-97 of the Thermus flavus 5S rRNA including, a hairpin loop. The RNA structure determined at 3.0 A and refined to an, R-value of 24.1% also represents the first X-ray structure GNRA tetraloop., The loop is in distinctly different conformation from other GNRA, tetraloops analyzed by NMR. The conformation of the two molecules in the, asymmetric unit is influenced and stabilized by specific intermolecular, contacts. The structural features presented here give evidence for the, ability of RNA molecules to adapt to specific environments.
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The synthetic RNA fragment 5'-CUGGGCGG(GCGA)CCGCCUGG (nucleotides in parentheses indicate the loop region) corresponds to the natural sequence of domain E from nucleotides 79-97 of the Thermus flavus 5S rRNA including a hairpin loop. The RNA structure determined at 3.0 A and refined to an R-value of 24.1% also represents the first X-ray structure GNRA tetraloop. The loop is in distinctly different conformation from other GNRA tetraloops analyzed by NMR. The conformation of the two molecules in the asymmetric unit is influenced and stabilized by specific intermolecular contacts. The structural features presented here give evidence for the ability of RNA molecules to adapt to specific environments.
==About this Structure==
==About this Structure==
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[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Betzel, C.]]
[[Category: Betzel, C.]]
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[[Category: Erdmann, V.A.]]
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[[Category: Erdmann, V A.]]
[[Category: Lorenz, S.]]
[[Category: Lorenz, S.]]
[[Category: Nolte, A.]]
[[Category: Nolte, A.]]
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[[Category: tetraloop]]
[[Category: tetraloop]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jan 29 21:36:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 19:02:18 2008''

Revision as of 17:02, 21 February 2008

Image:361d.gif

361d, resolution 3.000Å

Drag the structure with the mouse to rotate

CRYSTAL STRUCTURE OF DOMAIN E OF THERMUS FLAVUS 5S RRNA: A HELICAL RNA-STRUCTURE INCLUDING A TETRALOOP

Overview

The synthetic RNA fragment 5'-CUGGGCGG(GCGA)CCGCCUGG (nucleotides in parentheses indicate the loop region) corresponds to the natural sequence of domain E from nucleotides 79-97 of the Thermus flavus 5S rRNA including a hairpin loop. The RNA structure determined at 3.0 A and refined to an R-value of 24.1% also represents the first X-ray structure GNRA tetraloop. The loop is in distinctly different conformation from other GNRA tetraloops analyzed by NMR. The conformation of the two molecules in the asymmetric unit is influenced and stabilized by specific intermolecular contacts. The structural features presented here give evidence for the ability of RNA molecules to adapt to specific environments.

About this Structure

361D is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.

Reference

Crystal structure of domain E of Thermus flavus 5S rRNA: a helical RNA structure including a hairpin loop., Perbandt M, Nolte A, Lorenz S, Bald R, Betzel C, Erdmann VA, FEBS Lett. 1998 Jun 12;429(2):211-5. PMID:9650592

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