Response regulator
From Proteopedia
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'''Response regulators''' (RR) are part of the two-component signal transduction systems which enable bacteria to sense and respond to a wide range of environments. | '''Response regulators''' (RR) are part of the two-component signal transduction systems which enable bacteria to sense and respond to a wide range of environments. | ||
| - | Two-component RR is a complex of histidine kinase (sensor protein SP) and RR. The RR act as phosphorylation-activated switches. Most RR consist of N terminal shich is the signal receiving domain and C terminal which is the DNA-binding domain. | + | Two-component RR is a complex of histidine kinase (sensor protein SP) and RR. The RR act as phosphorylation-activated switches. Most RR consist of N terminal shich is the signal receiving domain and C terminal which is the DNA-binding domain. RR CheY is a chemotaxis response regulator in bacteria. RR Spo0 is the sporulation response regulator. Details on response regulator PleD see [[PleD activation]], [[PleD allosteric product inhibition]], [[PleD catalysis]]. For details on PhoP see [[PhoP Regulatory Domain]] and [[PhoP-PhoQ]]. |
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== 3D Structures of response regulator == | == 3D Structures of response regulator == | ||
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| + | ''Updated December 2011'' | ||
[[3sft]] – TmCheB methyltransferase catalytic domain – ''Thermotoga maritima''<br /> | [[3sft]] – TmCheB methyltransferase catalytic domain – ''Thermotoga maritima''<br /> | ||
| + | [[1u0s]] – TmCheA + CheY<br /> | ||
[[1p2f]] – TmDrrB<br /> | [[1p2f]] – TmDrrB<br /> | ||
| + | [[1kgs]] - TmDrrD<br /> | ||
[[3gl9]], [[3dgf]] – TmRR<br /> | [[3gl9]], [[3dgf]] – TmRR<br /> | ||
[[3snk]] – CheY-like – ''Mesorhizobium loti''<br /> | [[3snk]] – CheY-like – ''Mesorhizobium loti''<br /> | ||
| - | [[3crn]], [[3cg4]] - CheY-like – ''Methanospirillum hungatei''<br /> | + | [[1fc3]], [[1dz3]], [[1qmp]] – BsSpo0A - ''Bacillus subtilis''<br /> |
| + | [3crn]], [[3cg4]] - CheY-like – ''Methanospirillum hungatei''<br /> | ||
[[1ixm]] – BsSpo0B<br /> | [[1ixm]] – BsSpo0B<br /> | ||
[[1nat]] – BsSPo0F<br /> | [[1nat]] – BsSPo0F<br /> | ||
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[[1xhe]] – EcArcA (mutant) - ''Escherichia coli''<br /> | [[1xhe]] – EcArcA (mutant) - ''Escherichia coli''<br /> | ||
[[1jbe]] - EcCheY<br /> | [[1jbe]] - EcCheY<br /> | ||
| + | [[1mih]] - EcCheY (mutant)<br /> | ||
[[1nxo]], [[1nxp]], [[1nxs]], [[1nxt]], [[1nxv]], [[1nxw]], [[1nxx]] – SpRR MICA receiver domain<br /> | [[1nxo]], [[1nxp]], [[1nxs]], [[1nxt]], [[1nxv]], [[1nxw]], [[1nxx]] – SpRR MICA receiver domain<br /> | ||
[[2gwr]] – MtMtrA - ''Mycobacterium tuberculosis''<br /> | [[2gwr]] – MtMtrA - ''Mycobacterium tuberculosis''<br /> | ||
| + | [[3c3w]] – MtDosR <br /> | ||
| + | [[2y79]] – MtDooS GAP domain (mutant)<br /> | ||
[[1ys6]] – MtPrrA<br /> | [[1ys6]] – MtPrrA<br /> | ||
[[1k66]] – ToRcpB – ''Tolypothrix''<br /> | [[1k66]] – ToRcpB – ''Tolypothrix''<br /> | ||
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[[3p01]] – RR residues 134-315 – ''Nostoc''<br /> | [[3p01]] – RR residues 134-315 – ''Nostoc''<br /> | ||
[[3ilh]] – RR – ''Cytophaga hutchinsonii''<br /> | [[3ilh]] – RR – ''Cytophaga hutchinsonii''<br /> | ||
| - | [[3c3w]] – MtDosR <br /> | ||
[[2qvg]] – RR – ''Legionella pneumophila''<br /> | [[2qvg]] – RR – ''Legionella pneumophila''<br /> | ||
[[2qr3]] – RR – ''Bacterioides fragilis''<br /> | [[2qr3]] – RR – ''Bacterioides fragilis''<br /> | ||
| + | [[2chy]] – CheY – ''Salmonella typhimurium'' | ||
===Response regulator signal receiving domain=== | ===Response regulator signal receiving domain=== | ||
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[[2zwm]]– BsYycF <br /> | [[2zwm]]– BsYycF <br /> | ||
[[1mvo]] - BsPhoP <br /> | [[1mvo]] - BsPhoP <br /> | ||
| + | [[2pkx]] - EcPhoP <br /> | ||
[[3gkg]], [[2i6f]] – MxFrzS <br /> | [[3gkg]], [[2i6f]] – MxFrzS <br /> | ||
[[2nt3]], [[2nt4]] - MxFrzS (mutant) <br /> | [[2nt3]], [[2nt4]] - MxFrzS (mutant) <br /> | ||
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[[1umq]] – PrrA – ''Rhodobacter sphaeroides'' – NMR<BR /> | [[1umq]] – PrrA – ''Rhodobacter sphaeroides'' – NMR<BR /> | ||
[[3c57]] – MtDosR <br /> | [[3c57]] – MtDosR <br /> | ||
| - | [[2pmu]] – MtPhoP | + | [[3zxo]] – MtDosS<br /> |
| + | [[3zxq]] – MtDosT<br /> | ||
| + | [[2pmu]] – MtPhoP<br /> | ||
| + | [[1irz]] – Arr10-B – ''Arabidopsis thaliana'' - NMR | ||
===Response regulator complex=== | ===Response regulator complex=== | ||
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[[3a10]] - TmTrrA (mutant) + Mg + BeF3<br /> | [[3a10]] - TmTrrA (mutant) + Mg + BeF3<br /> | ||
[[3rqi]] – RR + phosphorylated aspartic acid + citrate + Ca – ''Burkholderia pseudomallei''<br /> | [[3rqi]] – RR + phosphorylated aspartic acid + citrate + Ca – ''Burkholderia pseudomallei''<br /> | ||
| - | [[3q15]] – BsRapH + sporulation initiation phosphotransferase | + | [[3q15]] – BsRapH + sporulation initiation phosphotransferase <br /> |
[[3m6m]] – RpfF residues 400-541 + RpfF protein REC domain – ''Xanthomonas campestris''<br /> | [[3m6m]] – RpfF residues 400-541 + RpfF protein REC domain – ''Xanthomonas campestris''<br /> | ||
[[1mav]], [[1mb0]], [[1mb3]] – CvDivK + metal ion<br /> | [[1mav]], [[1mb0]], [[1mb3]] – CvDivK + metal ion<br /> | ||
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[[3dge]] – TmRR + SP cytoplasmic domain<br /> | [[3dge]] – TmRR + SP cytoplasmic domain<br /> | ||
[[3a0r]] – TmTrrA + histidine kinase ThkA<br /> | [[3a0r]] – TmTrrA + histidine kinase ThkA<br /> | ||
| - | [[1zg1]], [[1zg5]], [[1je8]] – EcNarL DNA-binding domain + DNA | + | [[1zg1]], [[1zg5]], [[1je8]] – EcNarL DNA-binding domain + DNA<br /> |
| + | [[1p6q]] – SmChey2 + Mg – ''Sinorhizobium meliloti'' – NMR<br /> | ||
| + | [[1p6u]] – SmChey2 + Mg + BeF3 – NMR | ||
Revision as of 09:52, 15 December 2011
Response regulators (RR) are part of the two-component signal transduction systems which enable bacteria to sense and respond to a wide range of environments. Two-component RR is a complex of histidine kinase (sensor protein SP) and RR. The RR act as phosphorylation-activated switches. Most RR consist of N terminal shich is the signal receiving domain and C terminal which is the DNA-binding domain. RR CheY is a chemotaxis response regulator in bacteria. RR Spo0 is the sporulation response regulator. Details on response regulator PleD see PleD activation, PleD allosteric product inhibition, PleD catalysis. For details on PhoP see PhoP Regulatory Domain and PhoP-PhoQ.
Contents |
3D Structures of response regulator
Updated December 2011
3sft – TmCheB methyltransferase catalytic domain – Thermotoga maritima
1u0s – TmCheA + CheY
1p2f – TmDrrB
1kgs - TmDrrD
3gl9, 3dgf – TmRR
3snk – CheY-like – Mesorhizobium loti
1fc3, 1dz3, 1qmp – BsSpo0A - Bacillus subtilis
[3crn]], 3cg4 - CheY-like – Methanospirillum hungatei
1ixm – BsSpo0B
1nat – BsSPo0F
1srr - BsSPo0F (mutant)
3p3q – McMmoQ (mutant) – Methylococcus capsulatus
3ljx – McMmoQ residues 20-298
3n0r – CvPhyR – Caulobacter vibrioides
1m5t, 1m5u - CvDivK
3n53 – RR – Pelobacter carbinolicus
3nhm – MxRR – Myxococcus xanthus
3kto - RR – Pseudoalteromonas atlantica
3f7a, 3eq2 – PaRssB – Pseudomonas aeruginosa
3es2 – PaRssB phosphatase domain
3i5b – PaWpsR GGDEF domain
3i5c - PaWpsR GGDEF domain/GCN4 leucine zipper
1yio, 1zn2 – PfStyR – Pseudomonas fluorescens
3hdv – RR – Pseudomonas putida
3i5a – WpsR – Pseudomonas syringae
3heb – CheY – Rhodospirillum rubrum
3eqz – CpRR – Colwellia psychrerythraea
2zay – RR residues 150-285 – Desulfuromonas acetoxidans
2rdm – RR (mutant) – Sinorhizobium medicae
1xhe – EcArcA (mutant) - Escherichia coli
1jbe - EcCheY
1mih - EcCheY (mutant)
1nxo, 1nxp, 1nxs, 1nxt, 1nxv, 1nxw, 1nxx – SpRR MICA receiver domain
2gwr – MtMtrA - Mycobacterium tuberculosis
3c3w – MtDosR
2y79 – MtDooS GAP domain (mutant)
1ys6 – MtPrrA
1k66 – ToRcpB – Tolypothrix
1k68 – ToRcpA
3p01 – RR residues 134-315 – Nostoc
3ilh – RR – Cytophaga hutchinsonii
2qvg – RR – Legionella pneumophila
2qr3 – RR – Bacterioides fragilis
2chy – CheY – Salmonella typhimurium
Response regulator signal receiving domain
2qxy – TmRR
3i42 - CheY-like – Methylobacillus flagellatus
2zwm– BsYycF
1mvo - BsPhoP
2pkx - EcPhoP
3gkg, 2i6f – MxFrzS
2nt3, 2nt4 - MxFrzS (mutant)
3lte – RR – Bermanella marisrubri
3hv2 – PfRR
3kht – RR – Hahella chejuensis
3jte – CtRR - Clostridium thermocellum
3cnb – CpRR
3c3m – RR – Methanoculleus marisnigri
2qsj – LuxR – Silicibacter pomeroyi
2pln – RR – Helicobacter pylori
2jb9, 2jba – EcPhoB (mutant)
3lua – CtRR
3lsg – YesN – Fusobacterium nucleatum
3cz5 – LuxR – Aurantimonas
2qzj – RR – Clostridium difficile
1a04, 1rnl – EcNarL
Response regulator DNA-binding domain
2zxj - SaYycF - Staphylococcus aureus
2rnj - SaVraR - NMR
2hwv – VicR – Enterococcus faecalis
1umq – PrrA – Rhodobacter sphaeroides – NMR
3c57 – MtDosR
3zxo – MtDosS
3zxq – MtDosT
2pmu – MtPhoP
1irz – Arr10-B – Arabidopsis thaliana - NMR
Response regulator complex
3nnn – TmDrrD signal receiving domain + BeF3
3nns – TmDrrB signal receiving domain + BeF3
3a0u - TmTrrA + Mg + BeF3
3a10 - TmTrrA (mutant) + Mg + BeF3
3rqi – RR + phosphorylated aspartic acid + citrate + Ca – Burkholderia pseudomallei
3q15 – BsRapH + sporulation initiation phosphotransferase
3m6m – RpfF residues 400-541 + RpfF protein REC domain – Xanthomonas campestris
1mav, 1mb0, 1mb3 – CvDivK + metal ion
2wb4 – PleD + cyclic diguanosine monophosphate + BeF3 – Caulobacter crescentus
2v0n – CvPleD residues 2-454 + cyclic diguanosine monophosphate + GTP + BeF3
3hzh – CheX + CheY + Mg + BeF3 – Borrelia burgdorferi
1xhf - EcArcA (mutant) + BeF3
2a9o, 2a9p, 2a9q, 2a9r – SpYycF + BeF3 – Streptococcus pneumoniae
1ys7 – MtPrrA + Mg
1jlk, 1i3c – Rcp1 + Mn]] - Synechocystis
3dge – TmRR + SP cytoplasmic domain
3a0r – TmTrrA + histidine kinase ThkA
1zg1, 1zg5, 1je8 – EcNarL DNA-binding domain + DNA
1p6q – SmChey2 + Mg – Sinorhizobium meliloti – NMR
1p6u – SmChey2 + Mg + BeF3 – NMR
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