2w1k

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[[Image:2w1k.png|left|200px]]
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==CRYSTAL STRUCTURE OF SORTASE C-3 (SRTC-3) FROM STREPTOCOCCUS PNEUMONIAE==
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<StructureSection load='2w1k' size='340' side='right' caption='[[2w1k]], [[Resolution|resolution]] 2.14&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2w1k]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W1K OCA]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene><br>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w1k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w1k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w1k RCSB], [http://www.ebi.ac.uk/pdbsum/2w1k PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Streptococcus pneumoniae is a piliated pathogen whose ability to circumvent vaccination and antibiotic treatment strategies is a cause of mortality worldwide. Pili play important roles in pneumococcal infection, but little is known about their biogenesis mechanism or the relationship between components of the pilus-forming machinery, which includes the fiber pilin (RrgB), two minor pilins (RrgA, RrgC), and three sortases (SrtC-1, SrtC-2, SrtC-3). Here we show that SrtC-1 is the main pilus-polymerizing transpeptidase, and electron microscopy analyses of RrgB fibers reconstituted in vitro reveal that they structurally mimic the pneumococcal pilus backbone. Crystal structures of both SrtC-1 and SrtC-3 reveal active sites whose access is controlled by flexible lids, unlike in non-pilus sortases, and suggest that substrate specificity is dictated by surface recognition coupled to lid opening. The distinct structural features of pilus-forming sortases suggest a common pilus biogenesis mechanism that could be exploited for the development of broad-spectrum antibacterials.
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Sortase-Mediated Pilus Fiber Biogenesis in Streptococcus pneumoniae.,Manzano C, Contreras-Martel C, El Mortaji L, Izore T, Fenel D, Vernet T, Schoehn G, Di Guilmi AM, Dessen A Structure. 2008 Dec 12;16(12):1838-48. PMID:19081060<ref>PMID:19081060</ref>
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The line below this paragraph, containing "STRUCTURE_2w1k", creates the "Structure Box" on the page.
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{{STRUCTURE_2w1k| PDB=2w1k | SCENE= }}
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===CRYSTAL STRUCTURE OF SORTASE C-3 (SRTC-3) FROM STREPTOCOCCUS PNEUMONIAE===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_19081060}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 19081060 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_19081060}}
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==About this Structure==
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[[2w1k]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W1K OCA].
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==Reference==
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<ref group="xtra">PMID:019081060</ref><references group="xtra"/>
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[[Category: Peptidyltransferase]]
[[Category: Peptidyltransferase]]
[[Category: Streptococcus pneumoniae]]
[[Category: Streptococcus pneumoniae]]

Revision as of 08:34, 7 May 2014

CRYSTAL STRUCTURE OF SORTASE C-3 (SRTC-3) FROM STREPTOCOCCUS PNEUMONIAE

2w1k, resolution 2.14Å

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