2jfb

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[[Image:2jfb.png|left|200px]]
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==3D STRUCTURE OF LUMAZINE SYNTHASE FROM CANDIDA ALBICANS==
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<StructureSection load='2jfb' size='340' side='right' caption='[[2jfb]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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[[2jfb]] is a 15 chain structure with sequence from [http://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JFB OCA]. <br>
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<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jf/2jfb_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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== Publication Abstract from PubMed ==
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Lumazine synthase is an enzyme involved in riboflavin biosynthesis in many plants and microorganisms, including numerous human pathogens. The fact that the enzymes of the riboflavin biosynthesis pathway are not present in the human or animal host makes them potential targets for anti-infective agents. The crystal structure of lumazine synthase from Candida albicans was solved by molecular replacement and refined at 2.5-Angstrom resolution. The results of crystallographic investigations and sedimentation equilibrium experiments clearly indicated the presence of pentameric assemblies of the enzyme either in crystals or in solution. Isothermal titration calorimetry measurements of the binding reactions of four different inhibitors revealed high affinity for all four compounds with binding constants in the micromolar range. Structural comparison with previously determined structures of the enzyme.ligand complexes of other orthologue allowed modeling of the binding of four different inhibitors into the active site of lumazine synthase from Candida albicans.
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Lumazine synthase from Candida albicans as an anti-fungal target enzyme: structural and biochemical basis for drug design.,Morgunova E, Saller S, Haase I, Cushman M, Bacher A, Fischer M, Ladenstein R J Biol Chem. 2007 Jun 8;282(23):17231-41. Epub 2007 Apr 18. PMID:17446177<ref>PMID:17446177</ref>
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The line below this paragraph, containing "STRUCTURE_2jfb", creates the "Structure Box" on the page.
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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-->
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{{STRUCTURE_2jfb| PDB=2jfb | SCENE= }}
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===3D STRUCTURE OF LUMAZINE SYNTHASE FROM CANDIDA ALBICANS===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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== References ==
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<references/>
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<!--
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__TOC__
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The line below this paragraph, {{ABSTRACT_PUBMED_17446177}}, adds the Publication Abstract to the page
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 17446177 is the PubMed ID number.
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-->
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{{ABSTRACT_PUBMED_17446177}}
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==About this Structure==
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[[2jfb]] is a 15 chain structure with sequence from [http://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JFB OCA].
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==Reference==
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<ref group="xtra">PMID:017446177</ref><references group="xtra"/>
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[[Category: Candida albicans]]
[[Category: Candida albicans]]
[[Category: Riboflavin synthase]]
[[Category: Riboflavin synthase]]

Revision as of 08:21, 30 April 2014

3D STRUCTURE OF LUMAZINE SYNTHASE FROM CANDIDA ALBICANS

2jfb, resolution 2.50Å

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