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2ivf

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[[Image:2ivf.png|left|200px]]
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==ETHYLBENZENE DEHYDROGENASE FROM AROMATOLEUM AROMATICUM==
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<StructureSection load='2ivf' size='340' side='right' caption='[[2ivf]], [[Resolution|resolution]] 1.88&Aring;' scene=''>
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== Structural highlights ==
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[[2ivf]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Aromatoleum_aromaticum Aromatoleum aromaticum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IVF OCA]. <br>
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<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iv/2ivf_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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== Publication Abstract from PubMed ==
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Anaerobic degradation of hydrocarbons was discovered a decade ago, and ethylbenzene dehydrogenase was one of the first characterized enzymes involved. The structure of the soluble periplasmic 165 kDa enzyme was established at 1.88 A resolution. It is a heterotrimer. The alpha subunit contains the catalytic center with a molybdenum held by two molybdopterin-guanine dinucleotides, one with an open pyran ring, and an iron-sulfur cluster with a histidine ligand. During catalysis, electrons produced by substrate oxidation are transferred to a heme in the gamma subunit and then presumably to a separate cytochrome involved in nitrate respiration. The beta subunit contains four iron-sulfur clusters and is structurally related to ferredoxins. The gamma subunit is the first known protein with a methionine and a lysine as axial heme ligands. The catalytic product was modeled into the active center, showing the reaction geometry. A mechanism consistent with activity and inhibition data of ethylbenzene-related compounds is proposed.
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<!--
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Crystal structure of ethylbenzene dehydrogenase from Aromatoleum aromaticum.,Kloer DP, Hagel C, Heider J, Schulz GE Structure. 2006 Sep;14(9):1377-88. PMID:16962969<ref>PMID:16962969</ref>
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The line below this paragraph, containing "STRUCTURE_2ivf", creates the "Structure Box" on the page.
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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-->
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{{STRUCTURE_2ivf| PDB=2ivf | SCENE= }}
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===ETHYLBENZENE DEHYDROGENASE FROM AROMATOLEUM AROMATICUM===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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== References ==
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<references/>
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<!--
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__TOC__
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The line below this paragraph, {{ABSTRACT_PUBMED_16962969}}, adds the Publication Abstract to the page
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 16962969 is the PubMed ID number.
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-->
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{{ABSTRACT_PUBMED_16962969}}
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==About this Structure==
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[[2ivf]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Aromatoleum_aromaticum Aromatoleum aromaticum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IVF OCA].
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==Reference==
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<ref group="xtra">PMID:016962969</ref><references group="xtra"/>
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[[Category: Aromatoleum aromaticum]]
[[Category: Aromatoleum aromaticum]]
[[Category: Ethylbenzene hydroxylase]]
[[Category: Ethylbenzene hydroxylase]]

Revision as of 08:30, 30 April 2014

ETHYLBENZENE DEHYDROGENASE FROM AROMATOLEUM AROMATICUM

2ivf, resolution 1.88Å

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