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3qva

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[[Image:3qva.jpg|left|200px]]
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==Structure of Klebsiella pneumoniae 5-hydroxyisourate hydrolase==
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<StructureSection load='3qva' size='340' side='right' caption='[[3qva]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3qva]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Klebsiella_pneumoniae_subsp._pneumoniae Klebsiella pneumoniae subsp. pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QVA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QVA FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HpxT, KPN78578_16360, KPN_01666 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=72407 Klebsiella pneumoniae subsp. pneumoniae])</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qva OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qva RCSB], [http://www.ebi.ac.uk/pdbsum/3qva PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The stereospecific oxidative degradation of uric acid to (S)-allantoin has recently been demonstrated to proceed via two unstable intermediates and requires three separate enzymatic reactions. The second step of this reaction, the conversion of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline, is catalyzed by HIU hydrolase (HIUH). The high-resolution crystal structure of HIUH from the opportunistic pathogen Klebsiella pneumoniae (KpHIUH) has been determined. KpHIUH is a homotetrameric protein that, based on sequence and structural similarity, belongs to the transthyretin-related protein family. In addition, the steady-state kinetic parameters for this enzyme and four active-site mutants have been measured. These data provide valuable insight into the functional roles of the active-site residues. Based upon the structural and kinetic data, a mechanism is proposed for the KpHIUH-catalyzed reaction.
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Structural and kinetic insights into the mechanism of 5-hydroxyisourate hydrolase from Klebsiella pneumoniae.,French JB, Ealick SE Acta Crystallogr D Biol Crystallogr. 2011 Aug;67(Pt 8):671-7. Epub 2011, Jul 12. PMID:21795808<ref>PMID:21795808</ref>
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The line below this paragraph, containing "STRUCTURE_3qva", creates the "Structure Box" on the page.
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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{{STRUCTURE_3qva| PDB=3qva | SCENE= }}
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===Structure of Klebsiella pneumoniae 5-hydroxyisourate hydrolase===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_21795808}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 21795808 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_21795808}}
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==About this Structure==
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[[3qva]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Klebsiella_pneumoniae_subsp._pneumoniae Klebsiella pneumoniae subsp. pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QVA OCA].
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==Reference==
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<ref group="xtra">PMID:021795808</ref><references group="xtra"/>
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[[Category: Klebsiella pneumoniae subsp. pneumoniae]]
[[Category: Klebsiella pneumoniae subsp. pneumoniae]]
[[Category: Ealick, S E.]]
[[Category: Ealick, S E.]]

Revision as of 04:39, 5 June 2014

Structure of Klebsiella pneumoniae 5-hydroxyisourate hydrolase

3qva, resolution 1.75Å

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