2xf1

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2xf1.png|left|200px]]
+
==CRYSTAL STRUCTURE OF PLASMODIUM FALCIPARUM ACTIN DEPOLYMERIZATION FACTOR 1==
 +
<StructureSection load='2xf1' size='340' side='right' caption='[[2xf1]], [[Resolution|resolution]] 1.96&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[2xf1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XF1 OCA]. <br>
 +
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
 +
<tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr>
 +
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
 +
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xf1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xf1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xf1 RCSB], [http://www.ebi.ac.uk/pdbsum/2xf1 PDBsum]</span></td></tr>
 +
<table>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Apicomplexan parasites, such as the malaria-causing Plasmodium, utilize an actin-based motor for motility and host cell invasion. The actin filaments of these parasites are unusually short, and actin polymerization is under strict control of a small set of regulatory proteins, which are poorly conserved with their mammalian orthologs. Actin depolymerization factors (ADFs) are among the most important actin regulators, affecting the rates of filament turnover in a multifaceted manner. Plasmodium has two ADFs that display low sequence homology with each other and with the higher eukaryotic family members. Here, we show that ADF2, like canonical ADF proteins but unlike ADF1, binds to both globular and filamentous actin, severing filaments and inducing nucleotide exchange on the actin monomer. The crystal structure of Plasmodium ADF1 shows major differences from the ADF consensus, explaining the lack of F-actin binding. Plasmodium ADF2 structurally resembles the canonical members of the ADF/cofilin family.
-
<!--
+
Crystal structures explain functional differences in the two actin depolymerization factors of the malaria parasite.,Singh BK, Sattler JM, Chatterjee M, Huttu J, Schuler H, Kursula I J Biol Chem. 2011 Aug 12;286(32):28256-64. PMID:21832095<ref>PMID:21832095</ref>
-
The line below this paragraph, containing "STRUCTURE_2xf1", creates the "Structure Box" on the page.
+
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
-
or leave the SCENE parameter empty for the default display.
+
-
-->
+
-
{{STRUCTURE_2xf1| PDB=2xf1 | SCENE= }}
+
-
===CRYSTAL STRUCTURE OF PLASMODIUM FALCIPARUM ACTIN DEPOLYMERIZATION FACTOR 1===
+
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-
 
+
</div>
-
 
+
== References ==
-
<!--
+
<references/>
-
The line below this paragraph, {{ABSTRACT_PUBMED_21832095}}, adds the Publication Abstract to the page
+
__TOC__
-
(as it appears on PubMed at http://www.pubmed.gov), where 21832095 is the PubMed ID number.
+
</StructureSection>
-
-->
+
-
{{ABSTRACT_PUBMED_21832095}}
+
-
 
+
-
==About this Structure==
+
-
[[2xf1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XF1 OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:021832095</ref><references group="xtra"/>
+
[[Category: Plasmodium falciparum]]
[[Category: Plasmodium falciparum]]
[[Category: Chatterjee, M.]]
[[Category: Chatterjee, M.]]

Revision as of 07:49, 14 May 2014

CRYSTAL STRUCTURE OF PLASMODIUM FALCIPARUM ACTIN DEPOLYMERIZATION FACTOR 1

2xf1, resolution 1.96Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2xf1"
Views
Personal tools
Navigation
Toolbox