2k0v

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[[Image:2k0v.png|left|200px]]
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==High Resolution Solution NMR Structures of Undamaged DNA Dodecamer Duplex==
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<StructureSection load='2k0v' size='340' side='right' caption='[[2k0v]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>
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== Structural highlights ==
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[[2k0v]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K0V OCA]. <br>
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<b>Related:</b> [[2k0t|2k0t]], [[2k0u|2k0u]], [[2k0w|2k0w]]<br>
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<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>
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== Publication Abstract from PubMed ==
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The differences in efficacy and molecular mechanisms of platinum anti-cancer drugs cisplatin (CP) and oxaliplatin (OX) are thought to be partially due to the differences in the DNA conformations of the CP and OX adducts that form on adjacent guanines on DNA, which in turn influence the binding of damage-recognition proteins that control downstream effects of the adducts. Here we report a comprehensive comparison of the structural distortion of DNA caused by CP and OX adducts in the TGGT sequence context using nuclear magnetic resonance (NMR) spectroscopy and molecular dynamics (MD) simulations. When compared to our previous studies in other sequence contexts, these structural studies help us understand the effect of the sequence context on the conformation of Pt-GG DNA adducts. We find that both the sequence context and the type of Pt-GG DNA adduct (CP vs. OX) play an important role in the conformation and the conformational dynamics of Pt-DNA adducts, possibly explaining their influence on the ability of many damage-recognition proteins to bind to Pt-DNA adducts.
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Flanking Bases Influence the Nature of DNA Distortion by Platinum 1,2-Intrastrand (GG) Cross-Links.,Bhattacharyya D, Ramachandran S, Sharma S, Pathmasiri W, King CL, Baskerville-Abraham I, Boysen G, Swenberg JA, Campbell SL, Dokholyan NV, Chaney SG PLoS One. 2011;6(8):e23582. Epub 2011 Aug 10. PMID:21853154<ref>PMID:21853154</ref>
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The line below this paragraph, containing "STRUCTURE_2k0v", creates the "Structure Box" on the page.
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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{{STRUCTURE_2k0v| PDB=2k0v | SCENE= }}
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===High Resolution Solution NMR Structures of Undamaged DNA Dodecamer Duplex===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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== References ==
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<references/>
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__TOC__
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The line below this paragraph, {{ABSTRACT_PUBMED_21853154}}, adds the Publication Abstract to the page
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 21853154 is the PubMed ID number.
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{{ABSTRACT_PUBMED_21853154}}
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==About this Structure==
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[[2k0v]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K0V OCA].
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==Reference==
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<ref group="xtra">PMID:021853154</ref><references group="xtra"/>
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[[Category: Bhattacharyya, D.]]
[[Category: Bhattacharyya, D.]]
[[Category: Campbell, S L.]]
[[Category: Campbell, S L.]]

Revision as of 08:26, 30 April 2014

High Resolution Solution NMR Structures of Undamaged DNA Dodecamer Duplex

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