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1a8a
From Proteopedia
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==Overview== | ==Overview== | ||
| - | Structural evidence is presented for a 'Ca(2+)-bridging' mechanism, proposed for Ca(2+)-binding interfacial membrane proteins such as | + | Structural evidence is presented for a 'Ca(2+)-bridging' mechanism, proposed for Ca(2+)-binding interfacial membrane proteins such as annexins, protein kinase C, and certain coagulation proteins. Crystal structures of Ca(2+)-annexin V complexes with phospholipid polar heads provide molecular details of 'Ca(2+)-bridges' as key features in the membrane attachment exhibited by these proteins. Distinct binding sites for phospholipid head groups are observed, including a novel, double-Ca2+ recognition site for phosphoserine that may serve as a phosphatidylserine receptor site in vivo. |
==About this Structure== | ==About this Structure== | ||
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[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Concha, N | + | [[Category: Concha, N O.]] |
| - | [[Category: Dedman, J | + | [[Category: Dedman, J R.]] |
| - | [[Category: Kaetzel, M | + | [[Category: Kaetzel, M A.]] |
| - | [[Category: Seaton, B | + | [[Category: Seaton, B A.]] |
| - | [[Category: Swairjo, M | + | [[Category: Swairjo, M A.]] |
[[Category: CA]] | [[Category: CA]] | ||
[[Category: GSE]] | [[Category: GSE]] | ||
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[[Category: phospholipid analog]] | [[Category: phospholipid analog]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:42:00 2008'' |
Revision as of 09:42, 21 February 2008
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RAT ANNEXIN V COMPLEXED WITH GLYCEROPHOSPHOSERINE
Overview
Structural evidence is presented for a 'Ca(2+)-bridging' mechanism, proposed for Ca(2+)-binding interfacial membrane proteins such as annexins, protein kinase C, and certain coagulation proteins. Crystal structures of Ca(2+)-annexin V complexes with phospholipid polar heads provide molecular details of 'Ca(2+)-bridges' as key features in the membrane attachment exhibited by these proteins. Distinct binding sites for phospholipid head groups are observed, including a novel, double-Ca2+ recognition site for phosphoserine that may serve as a phosphatidylserine receptor site in vivo.
About this Structure
1A8A is a Single protein structure of sequence from Rattus norvegicus with and as ligands. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Ca(2+)-bridging mechanism and phospholipid head group recognition in the membrane-binding protein annexin V., Swairjo MA, Concha NO, Kaetzel MA, Dedman JR, Seaton BA, Nat Struct Biol. 1995 Nov;2(11):968-74. PMID:7583670
Page seeded by OCA on Thu Feb 21 11:42:00 2008
