3s2o
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
[[Image:3s2o.png|left|200px]] | [[Image:3s2o.png|left|200px]] | ||
| - | <!-- | ||
| - | The line below this paragraph, containing "STRUCTURE_3s2o", creates the "Structure Box" on the page. | ||
| - | You may change the PDB parameter (which sets the PDB file loaded into the applet) | ||
| - | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | ||
| - | or leave the SCENE parameter empty for the default display. | ||
| - | --> | ||
{{STRUCTURE_3s2o| PDB=3s2o | SCENE= }} | {{STRUCTURE_3s2o| PDB=3s2o | SCENE= }} | ||
===Fragment based discovery and optimisation of bace-1 inhibitors=== | ===Fragment based discovery and optimisation of bace-1 inhibitors=== | ||
| - | |||
| - | <!-- | ||
| - | The line below this paragraph, {{ABSTRACT_PUBMED_20656487}}, adds the Publication Abstract to the page | ||
| - | (as it appears on PubMed at http://www.pubmed.gov), where 20656487 is the PubMed ID number. | ||
| - | --> | ||
{{ABSTRACT_PUBMED_20656487}} | {{ABSTRACT_PUBMED_20656487}} | ||
| Line 22: | Line 11: | ||
==See Also== | ==See Also== | ||
| - | *[[Beta secretase]] | + | *[[Beta secretase|Beta secretase]] |
==Reference== | ==Reference== | ||
Revision as of 00:53, 26 July 2012
Contents |
Fragment based discovery and optimisation of bace-1 inhibitors
Template:ABSTRACT PUBMED 20656487
About this Structure
3s2o is a 1 chain structure of Beta secretase with sequence from Homo sapiens. This structure supersedes the now removed PDB entry 3msm. Full crystallographic information is available from OCA.
See Also
Reference
- Madden J, Dod JR, Godemann R, Kraemer J, Smith M, Biniszkiewicz M, Hallett DJ, Barker J, Dyekjaer JD, Hesterkamp T. Fragment-based discovery and optimization of BACE1 inhibitors. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5329-33. Epub 2010 Jun 27. PMID:20656487 doi:10.1016/j.bmcl.2010.06.089
Categories: Homo sapiens | Memapsin 2 | Barker, J. | Godemann, R. | Hallett, D. | Kraemer, J. | Madden, J. | Smith, M A. | Alzheimer's disease | Amyloid precursor protein secretase | Aspartic endopeptidase | Aspartic protease | Aspartyl protease | Base | Beta-secretase | Fluorescence polarisation | Fragment-based drug design | Glycoprotein | Hydrolase-hydrolase inhibitor complex | Protease | Transmembrane
