This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3p53

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:3p53.png|left|200px]]
 
- 
-
<!--
 
-
The line below this paragraph, containing "STRUCTURE_3p53", creates the "Structure Box" on the page.
 
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
 
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
 
-
or leave the SCENE parameter empty for the default display.
 
-
-->
 
{{STRUCTURE_3p53| PDB=3p53 | SCENE= }}
{{STRUCTURE_3p53| PDB=3p53 | SCENE= }}
- 
===Structure of fascin===
===Structure of fascin===
 +
{{ABSTRACT_PUBMED_21685497}}
-
 
+
==Function==
-
<!--
+
[[http://www.uniprot.org/uniprot/FSCN1_HUMAN FSCN1_HUMAN]] Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration.<ref>PMID:9362073</ref> <ref>PMID:9571235</ref> <ref>PMID:20137952</ref> <ref>PMID:20393565</ref>
-
The line below this paragraph, {{ABSTRACT_PUBMED_21685497}}, adds the Publication Abstract to the page
+
-
(as it appears on PubMed at http://www.pubmed.gov), where 21685497 is the PubMed ID number.
+
-
-->
+
-
{{ABSTRACT_PUBMED_21685497}}
+
==About this Structure==
==About this Structure==
-
[[3p53]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P53 OCA].
+
[[3p53]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P53 OCA].
==Reference==
==Reference==
-
<ref group="xtra">PMID:021685497</ref><references group="xtra"/>
+
<ref group="xtra">PMID:021685497</ref><references group="xtra"/><references/>
-
[[Category: Homo sapiens]]
+
[[Category: Human]]
[[Category: Dominguez, R.]]
[[Category: Dominguez, R.]]
[[Category: Jansen, S.]]
[[Category: Jansen, S.]]
[[Category: Beta-trefoil domain]]
[[Category: Beta-trefoil domain]]
[[Category: Structural protein]]
[[Category: Structural protein]]

Revision as of 08:31, 16 April 2014

Template:STRUCTURE 3p53

Contents

Structure of fascin

Template:ABSTRACT PUBMED 21685497

Function

[FSCN1_HUMAN] Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration.[1] [2] [3] [4]

About this Structure

3p53 is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA.

Reference

  • Jansen S, Collins A, Yang C, Rebowski G, Svitkina T, Dominguez R. Mechanism of actin filament bundling by fascin. J Biol Chem. 2011 Aug 26;286(34):30087-96. Epub 2011 Jun 18. PMID:21685497 doi:10.1074/jbc.M111.251439
  1. ↑ Adams JC. Characterization of cell-matrix adhesion requirements for the formation of fascin microspikes. Mol Biol Cell. 1997 Nov;8(11):2345-63. PMID:9362073
  2. ↑ Yamashiro S, Yamakita Y, Ono S, Matsumura F. Fascin, an actin-bundling protein, induces membrane protrusions and increases cell motility of epithelial cells. Mol Biol Cell. 1998 May;9(5):993-1006. PMID:9571235
  3. ↑ Li A, Dawson JC, Forero-Vargas M, Spence HJ, Yu X, Konig I, Anderson K, Machesky LM. The actin-bundling protein fascin stabilizes actin in invadopodia and potentiates protrusive invasion. Curr Biol. 2010 Feb 23;20(4):339-45. doi: 10.1016/j.cub.2009.12.035. Epub 2010, Feb 4. PMID:20137952 doi:10.1016/j.cub.2009.12.035
  4. ↑ Chen L, Yang S, Jakoncic J, Zhang JJ, Huang XY. Migrastatin analogues target fascin to block tumour metastasis. Nature. 2010 Apr 15;464(7291):1062-6. PMID:20393565 doi:10.1038/nature08978

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3p53"
Personal tools