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2xhs

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[[Image:2xhs.png|left|200px]]
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==CRYSTAL STRUCTURE OF THE LIGAND BINDING DOMAIN OF FUSHI TARAZU FACTOR 1 OF DROSOPHILA MELANOGASTER.==
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<StructureSection load='2xhs' size='340' side='right' caption='[[2xhs]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2xhs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2iz2 2iz2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XHS OCA]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ftz|1ftz]], [[2iz2|2iz2]]</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xhs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xhs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xhs RCSB], [http://www.ebi.ac.uk/pdbsum/2xhs PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The interaction between the orphan nuclear receptor FTZ-F1 (Fushi tarazu factor 1) and the segmentation gene protein FTZ is critical for specifying alternate parasegments in the Drosophila embryo. Here, we have determined the structure of the FTZ-F1 ligand-binding domain (LBD).FTZ peptide complex using x-ray crystallography. Strikingly, the ligand-binding pocket of the FTZ-F1 LBD is completely occupied by helix 6 (H6) of the receptor, whereas the cofactor FTZ binds the co-activator cleft site of the FTZ-F1 LBD. Our findings suggest that H6 is essential for transcriptional activity of FTZ-F1; this is further supported by data from mutagenesis and activity assays. These data suggest that FTZ-F1 might belong to a novel class of ligand-independent nuclear receptors. Our findings are intriguing given that the highly homologous human steroidogenic factor-1 and liver receptor homolog-1 LBDs exhibit sizable ligand-binding pockets occupied by putative ligand molecules.
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Crystal structure of fushi tarazu factor 1 ligand binding domain/fushi tarazu Peptide complex identifies new class of nuclear receptors.,Yoo J, Ko S, Kim H, Sampson H, Yun JH, Choe KM, Chang I, Arrowsmith CH, Krause HM, Cho HS, Lee W J Biol Chem. 2011 Sep 9;286(36):31225-31. Epub 2011 Jul 20. PMID:21775434<ref>PMID:21775434</ref>
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The line below this paragraph, containing "STRUCTURE_2xhs", creates the "Structure Box" on the page.
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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{{STRUCTURE_2xhs| PDB=2xhs | SCENE= }}
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===CRYSTAL STRUCTURE OF THE LIGAND BINDING DOMAIN OF FUSHI TARAZU FACTOR 1 OF DROSOPHILA MELANOGASTER.===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<!--
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_21775434}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 21775434 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_21775434}}
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==About this Structure==
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[[2xhs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2iz2 2iz2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XHS OCA].
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==Reference==
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<ref group="xtra">PMID:021775434</ref><references group="xtra"/>
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[[Category: Drosophila melanogaster]]
[[Category: Drosophila melanogaster]]
[[Category: Cho, H S.]]
[[Category: Cho, H S.]]
[[Category: Yoo, J H.]]
[[Category: Yoo, J H.]]
[[Category: Transcription]]
[[Category: Transcription]]

Revision as of 07:42, 14 May 2014

CRYSTAL STRUCTURE OF THE LIGAND BINDING DOMAIN OF FUSHI TARAZU FACTOR 1 OF DROSOPHILA MELANOGASTER.

2xhs, resolution 2.80Å

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