3t9t

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'''Unreleased structure'''
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[[Image:3t9t.png|left|200px]]
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The entry 3t9t is ON HOLD until Paper Publication
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{{STRUCTURE_3t9t| PDB=3t9t | SCENE= }}
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Authors: Han, S., Caspers, N.
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===Crystal structure of BTK mutant (F435T,K596R) complexed with Imidazo[1,5-a]quinoxaline===
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Description: Crystal structure of BTK mutant (F435T,K596R) complexed with Imidazo[1,5-a]quinoxaline
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{{ABSTRACT_PUBMED_21958547}}
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==About this Structure==
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[[3t9t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T9T OCA].
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==Reference==
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<ref group="xtra">PMID:021958547</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
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[[Category: Non-specific protein-tyrosine kinase]]
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[[Category: Caspers, N.]]
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[[Category: Han, S.]]
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[[Category: Alpha/beta]]
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[[Category: Atp binding]]
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[[Category: Intracellular]]
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[[Category: Kinase domain]]
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[[Category: Phosphorylation]]
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[[Category: Transferase-transferase inhibitor complex]]

Revision as of 07:07, 30 October 2011

Image:3t9t.png

Template:STRUCTURE 3t9t

Crystal structure of BTK mutant (F435T,K596R) complexed with Imidazo[1,5-a]quinoxaline

Template:ABSTRACT PUBMED 21958547

About this Structure

3t9t is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Kim KH, Maderna A, Schnute ME, Hegen M, Mohan S, Miyashiro J, Lin L, Li E, Keegan S, Lussier J, Wrocklage C, Nickerson-Nutter CL, Wittwer AJ, Soutter H, Caspers N, Han S, Kurumbail R, Dunussi-Joannopoulos K, Douhan J 3rd, Wissner A. Imidazo[1,5-a]quinoxalines as irreversible BTK inhibitors for the treatment of rheumatoid arthritis. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6258-63. Epub 2011 Sep 10. PMID:21958547 doi:10.1016/j.bmcl.2011.09.008

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OCA

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