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1gve

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[[Image:1gve.png|left|200px]]
 
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{{STRUCTURE_1gve| PDB=1gve | SCENE= }}
{{STRUCTURE_1gve| PDB=1gve | SCENE= }}
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===AFLATOXIN ALDEHYDE REDUCTASE (AKR7A1) FROM RAT LIVER===
===AFLATOXIN ALDEHYDE REDUCTASE (AKR7A1) FROM RAT LIVER===
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{{ABSTRACT_PUBMED_11839745}}
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==Function==
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[[http://www.uniprot.org/uniprot/ARK73_RAT ARK73_RAT]] Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. Probably involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.<ref>PMID:12071861</ref>
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{{ABSTRACT_PUBMED_11839745}}
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==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:011839745</ref><ref group="xtra">PMID:008234296</ref><references group="xtra"/>
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<ref group="xtra">PMID:011839745</ref><references group="xtra"/><references/>
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Brown, E.]]
[[Category: Brown, E.]]

Revision as of 10:32, 16 April 2014

Template:STRUCTURE 1gve

Contents

AFLATOXIN ALDEHYDE REDUCTASE (AKR7A1) FROM RAT LIVER

Template:ABSTRACT PUBMED 11839745

Function

[ARK73_RAT] Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. Probably involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.[1]

About this Structure

1gve is a 2 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

  • Kozma E, Brown E, Ellis EM, Lapthorn AJ. The crystal structure of rat liver AKR7A1. A dimeric member of the aldo-keto reductase superfamily. J Biol Chem. 2002 May 3;277(18):16285-93. Epub 2002 Feb 11. PMID:11839745 doi:10.1074/jbc.M110808200
  1. ↑ Kelly VP, Sherratt PJ, Crouch DH, Hayes JD. Novel homodimeric and heterodimeric rat gamma-hydroxybutyrate synthases that associate with the Golgi apparatus define a distinct subclass of aldo-keto reductase 7 family proteins. Biochem J. 2002 Sep 15;366(Pt 3):847-61. PMID:12071861 doi:http://dx.doi.org/10.1042/BJ20020342

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