2xpp

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[[Image:2xpp.png|left|200px]]
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==CRYSTAL STRUCTURE OF A SPT6-IWS1(SPN1) COMPLEX FROM ENCEPHALITOZOON CUNICULI, FORM III==
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<StructureSection load='2xpp' size='340' side='right' caption='[[2xpp]], [[Resolution|resolution]] 1.74&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2xpp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Encephalitozoon_cuniculi Encephalitozoon cuniculi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XPP OCA]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2xpn|2xpn]], [[2xpl|2xpl]], [[2xpo|2xpo]]</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xpp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xpp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xpp RCSB], [http://www.ebi.ac.uk/pdbsum/2xpp PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Binding of elongation factor Spt6 to Iws1 provides an effective means for coupling eukaryotic mRNA synthesis, chromatin remodelling and mRNA export. We show that an N-terminal region of Spt6 (Spt6N) is responsible for interaction with Iws1. The crystallographic structures of Encephalitozoon cuniculi Iws1 and the Iws1/Spt6N complex reveal two conserved binding subdomains in Iws1. The first subdomain (one HEAT repeat; HEAT subdomain) is a putative phosphoprotein-binding site most likely involved in an Spt6-independent function of Iws1. The second subdomain (two ARM repeats; ARM subdomain) specifically recognizes a bipartite N-terminal region of Spt6. Mutations that alter this region of Spt6 cause severe phenotypes in vivo. Importantly, the ARM subdomain of Iws1 is conserved in several transcription factors, including TFIIS, Elongin A and Med26. We show that the homologous region in yeast TFIIS enables this factor to interact with SAGA and the Mediator subunits Spt8 and Med13, suggesting the molecular basis for TFIIS recruitment at promoters. Taken together, our results provide new structural information about the Iws1/Spt6 complex and reveal a novel interaction domain used for the formation of transcription networks.
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The structure of an Iws1/Spt6 complex reveals an interaction domain conserved in TFIIS, Elongin A and Med26.,Diebold ML, Koch M, Loeliger E, Cura V, Winston F, Cavarelli J, Romier C EMBO J. 2010 Dec 1;29(23):3979-91. Epub 2010 Nov 5. PMID:21057455<ref>PMID:21057455</ref>
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The line below this paragraph, containing "STRUCTURE_2xpp", creates the "Structure Box" on the page.
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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{{STRUCTURE_2xpp| PDB=2xpp | SCENE= }}
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===CRYSTAL STRUCTURE OF A SPT6-IWS1(SPN1) COMPLEX FROM ENCEPHALITOZOON CUNICULI, FORM III===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_21057455}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 21057455 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_21057455}}
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==About this Structure==
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[[2xpp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Encephalitozoon_cuniculi Encephalitozoon cuniculi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XPP OCA].
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==Reference==
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<ref group="xtra">PMID:021057455</ref><references group="xtra"/>
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[[Category: Encephalitozoon cuniculi]]
[[Category: Encephalitozoon cuniculi]]
[[Category: Cavarelli, J.]]
[[Category: Cavarelli, J.]]

Revision as of 07:51, 14 May 2014

CRYSTAL STRUCTURE OF A SPT6-IWS1(SPN1) COMPLEX FROM ENCEPHALITOZOON CUNICULI, FORM III

2xpp, resolution 1.74Å

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