1e18
From Proteopedia
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==Overview== | ==Overview== | ||
| - | DMSO reductase (DMSOR) from Rhodobacter capsulatus, well-characterised as | + | DMSO reductase (DMSOR) from Rhodobacter capsulatus, well-characterised as a molybdoenzyme, will bind tungsten. Protein crystallography has shown that tungsten in W-DMSOR is ligated by the dithiolene group of the two pyranopterins, the oxygen atom of Ser147 plus another oxygen atom, and is located in a very similar site to that of molybdenum in Mo-DMSOR. These conclusions are consistent with W L(III)-edge X-ray absorption, EPR and UV/visible spectroscopic data. W-DMSOR is significantly more active than Mo-DMSOR in catalysing the reduction of DMSO but, in contrast to the latter, shows no significant ability to catalyse the oxidation of DMS. |
==About this Structure== | ==About this Structure== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Bailey, S.]] | [[Category: Bailey, S.]] | ||
| - | [[Category: Stewart, L | + | [[Category: Stewart, L J.]] |
[[Category: 6WO]] | [[Category: 6WO]] | ||
[[Category: EOH]] | [[Category: EOH]] | ||
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[[Category: tungsten]] | [[Category: tungsten]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:22:40 2008'' |
Revision as of 10:22, 21 February 2008
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TUNGSTEN-SUSBSTITUTED DMSO REDUCTASE FROM RHODOBACTER CAPSULATUS
Overview
DMSO reductase (DMSOR) from Rhodobacter capsulatus, well-characterised as a molybdoenzyme, will bind tungsten. Protein crystallography has shown that tungsten in W-DMSOR is ligated by the dithiolene group of the two pyranopterins, the oxygen atom of Ser147 plus another oxygen atom, and is located in a very similar site to that of molybdenum in Mo-DMSOR. These conclusions are consistent with W L(III)-edge X-ray absorption, EPR and UV/visible spectroscopic data. W-DMSOR is significantly more active than Mo-DMSOR in catalysing the reduction of DMSO but, in contrast to the latter, shows no significant ability to catalyse the oxidation of DMS.
About this Structure
1E18 is a Single protein structure of sequence from Rhodobacter capsulatus with , and as ligands. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Dimethylsulfoxide reductase: an enzyme capable of catalysis with either molybdenum or tungsten at the active site., Stewart LJ, Bailey S, Bennett B, Charnock JM, Garner CD, McAlpine AS, J Mol Biol. 2000 Jun 9;299(3):593-600. PMID:10835270
Page seeded by OCA on Thu Feb 21 12:22:40 2008
Categories: Rhodobacter capsulatus | Single protein | Bailey, S. | Stewart, L J. | 6WO | EOH | PGD | Dmso | Molybdenum | Molybdopterin | Oxidoreductase | Reductase | Tungsten
