3p5y

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[[Image:3p5y.jpg|left|200px]]
 
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{{STRUCTURE_3p5y| PDB=3p5y | SCENE= }}
{{STRUCTURE_3p5y| PDB=3p5y | SCENE= }}
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===Crystal structure of the mutant T159A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP===
===Crystal structure of the mutant T159A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP===
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{{ABSTRACT_PUBMED_23030629}}
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==Function==
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[[http://www.uniprot.org/uniprot/PYRF_METTH PYRF_METTH]] Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).[HAMAP-Rule:MF_01200_A]
==About this Structure==
==About this Structure==
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[[3p5y]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Methanothermobacter_thermautotrophicus Methanothermobacter thermautotrophicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P5Y OCA].
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[[3p5y]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Methanothermobacter_thermautotrophicus_str._delta_h Methanothermobacter thermautotrophicus str. delta h]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P5Y OCA].
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[[Category: Methanothermobacter thermautotrophicus]]
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==Reference==
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<ref group="xtra">PMID:023030629</ref><references group="xtra"/><references/>
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[[Category: Methanothermobacter thermautotrophicus str. delta h]]
[[Category: Orotidine-5'-phosphate decarboxylase]]
[[Category: Orotidine-5'-phosphate decarboxylase]]
[[Category: Almo, S C.]]
[[Category: Almo, S C.]]

Revision as of 15:19, 19 June 2013

Template:STRUCTURE 3p5y

Contents

Crystal structure of the mutant T159A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP

Template:ABSTRACT PUBMED 23030629

Function

[PYRF_METTH] Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).[HAMAP-Rule:MF_01200_A]

About this Structure

3p5y is a 2 chain structure with sequence from Methanothermobacter thermautotrophicus str. delta h. Full crystallographic information is available from OCA.

Reference

  • Desai BJ, Wood BM, Fedorov AA, Fedorov EV, Goryanova B, Amyes TL, Richard JP, Almo SC, Gerlt JA. Conformational Changes in Orotidine 5'-Monophosphate Decarboxylase: A Structure-Based Explanation for How the 5'-Phosphate Group Activates the Enzyme. Biochemistry. 2012 Oct 17. PMID:23030629 doi:10.1021/bi301188k

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