Exonuclease
From Proteopedia
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== 3D Structures of exonuclease == | == 3D Structures of exonuclease == | ||
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===ExN-I=== | ===ExN-I=== | ||
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[[2qxf]] - EcExN-I + TMP<br /> | [[2qxf]] - EcExN-I + TMP<br /> | ||
[[3hl8]], [[3hp9]] - EcExN-I + inhibitor<br /> | [[3hl8]], [[3hp9]] - EcExN-I + inhibitor<br /> | ||
| - | [[3c94]] - EcExN-I + DNA-binding C terminal peptide | + | [[3c94]] - EcExN-I + DNA-binding C terminal peptide<br /> |
| + | [[3qe9]] – hExN-I (mutant) + DNA – human<br /> | ||
| + | [[3qea]], [[3qeb]] - hExN-I + DNA | ||
===ExN-III=== | ===ExN-III=== | ||
| - | [[2voa]] – | + | [[2voa]] – AfExN-III (mutant) + DNA – ''Archaeoglobus fulgidus''<br /> |
[[3g1k]] - MtExN-III – ''Methanothermobacter thermaautotrophicus''<br /> | [[3g1k]] - MtExN-III – ''Methanothermobacter thermaautotrophicus''<br /> | ||
[[3g3c]], [[3g4t]] - MtExN-III + DNA<br /> | [[3g3c]], [[3g4t]] - MtExN-III + DNA<br /> | ||
[[3fzi]], [[3g8v]], [[3g91]] - MtExN-III (mutant) <br /> | [[3fzi]], [[3g8v]], [[3g91]] - MtExN-III (mutant) <br /> | ||
[[3g00]], [[3g0r]], [[3g2c]], [[3g2d]], [[3g38]], [[3g3y]], [[3ga6]] - MtExN-III (mutant) + DNA<br /> | [[3g00]], [[3g0r]], [[3g2c]], [[3g2d]], [[3g38]], [[3g3y]], [[3ga6]] - MtExN-III (mutant) + DNA<br /> | ||
| - | [[3g0a]] - MtExN-III (mutant) + Mn | + | [[3g0a]] - MtExN-III (mutant) + Mn<br /> |
| + | [[1ako]] – EcExN-III | ||
===ExN-IV=== | ===ExN-IV=== | ||
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[[3h4r]] - EcExN-VIII C terminal (mutant) | [[3h4r]] - EcExN-VIII C terminal (mutant) | ||
| - | [[1ut5]], [[1ut8]] – 5’-ExN + metal – Bacteriophage T5 | + | ==Phage ExN=== |
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| + | [[1ut5]], [[1ut8]] – T5-5’-ExN + metal – Bacteriophage T5<br /> | ||
| + | [[1exn]], [[1xo1]] - T5-5’-ExN (mutant)<br /> | ||
| + | [[1avq]] – BlExN λ (mutant) – Bacteriophage λ<br /> | ||
| + | [[3slp]] - BlExN λ + DNA<br /> | ||
| + | [[3sm4]] - BlExN λ (mutant) + DNA<br /> | ||
| + | [[3k93]] – ExN – Haemophilus somnus | ||
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| + | ===Exosome complex ExN=== | ||
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| + | [[2ba1]] – AfExN Rrp41<br /> | ||
| + | [[2br2]] – SsExN-I + ExN-II – ''Sulfolobus solfataricus''<br /> | ||
| + | [[2jea]], [[2je6]], [[2jeb]] - SsExN-I (mutant) + ExN-II + RNA-binding protein 1<br /> | ||
| + | [[2hbj]], [[2hbk]], [[2hbl]], [[2hbm]] – yExN Rrp6 (mutant) <br /> | ||
| + | [[2ja9]] – yExN Rrp40<br /> | ||
| + | [[2vnu]] – yExN Rrp44 + DNA<br /> | ||
| + | [[2wp8]] - yExN Rrp45, Ski6, Dis3<br /> | ||
| + | [[2ioc]] - hExN Trex1 N terminal<br /> | ||
| + | [[2nn6]] – hExN Rrp41, Rrp45, Rrp42, Rrp40, Prp43, Rrp46, Mtr3, Csl4, Rrp4 | ||
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| + | ===Various ExN=== | ||
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| + | [[1ir6]], [[2zxo]], [[2zxp]], [[2zxr]] – ExN Recj – ''Thermus thermophiles''<br /> | ||
| + | [[1w0h]] – hExn Eri1 nuclease domain <br /> | ||
| + | [[1zbu]] - hExn Eri1<br /> | ||
| + | [[1zbh]] - hExn Eri1 (mutant) + DNA<br /> | ||
| + | [[1y97]] – hExN Trex2<br /> | ||
| + | [[2o4g]] - mExN Trex1 + nucleotide – mouse<br /> | ||
| + | [[3mxj]] - mExN Trex1<br /> | ||
| + | [[2o4i]], [[3mxi]], [[3mxm]] - mExN Trex1 (mutant) + DNA<br /> | ||
| + | [[2oa8]] - mExN Trex1 + DNA<br /> | ||
| + | [[3b6o]], [[3b6p]] - mExN Trex1 + ion inhibitor<br /> | ||
| + | [[2w45]] – H4ExN alkaline - Herpesvirus 4<br /> | ||
| + | [[2w4b]] - H4ExN alkaline (mutant)<br /> | ||
| + | [[3e2v]] – yExN - yeast | ||
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[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 10:52, 27 November 2011
Exonucleases (ExN) cleave nucleotides at the end of a polynucleotide chain. In E. coli there are ExN I to VIII. ExN-I cleaves single-stranded DNA; ExN-II is associated with DNA polymerase; ExN-III cleaves double-stranded DNA; ExN-IV cleavage results in nucleoside monophosphate; ExN-V cleaves linear double-stranded DNA; ExN-VIII requires a free 5’ OH group for reacting. ExN were found in human and yeast as well.
Contents |
3D Structures of exonuclease
Updated November 2011
ExN-I
1fxx, 3c95 – EcExN-I – Escherichia coli
2qxf - EcExN-I + TMP
3hl8, 3hp9 - EcExN-I + inhibitor
3c94 - EcExN-I + DNA-binding C terminal peptide
3qe9 – hExN-I (mutant) + DNA – human
3qea, 3qeb - hExN-I + DNA
ExN-III
2voa – AfExN-III (mutant) + DNA – Archaeoglobus fulgidus
3g1k - MtExN-III – Methanothermobacter thermaautotrophicus
3g3c, 3g4t - MtExN-III + DNA
3fzi, 3g8v, 3g91 - MtExN-III (mutant)
3g00, 3g0r, 3g2c, 3g2d, 3g38, 3g3y, 3ga6 - MtExN-III (mutant) + DNA
3g0a - MtExN-III (mutant) + Mn
1ako – EcExN-III
ExN-IV
2jc4 – ExN-IV – Nisseria meningitides
ExN-V
1w36, 3k70 – EcExN-V α+β+γ + DNA hairpin
3e1s - EcExN-V RECD subunit
3gp8 - DrExN-V RECD subunit + DNA – Deinococcus radiodurans
3gpl - DrExN-V RECD subunit + DNA + ADPNP
ExN-VII
1vp7 – ExN-VII small subunit – Bordetella pertussis
ExN-VIII
3h4r - EcExN-VIII C terminal (mutant)
Phage ExN=
1ut5, 1ut8 – T5-5’-ExN + metal – Bacteriophage T5
1exn, 1xo1 - T5-5’-ExN (mutant)
1avq – BlExN λ (mutant) – Bacteriophage λ
3slp - BlExN λ + DNA
3sm4 - BlExN λ (mutant) + DNA
3k93 – ExN – Haemophilus somnus
Exosome complex ExN
2ba1 – AfExN Rrp41
2br2 – SsExN-I + ExN-II – Sulfolobus solfataricus
2jea, 2je6, 2jeb - SsExN-I (mutant) + ExN-II + RNA-binding protein 1
2hbj, 2hbk, 2hbl, 2hbm – yExN Rrp6 (mutant)
2ja9 – yExN Rrp40
2vnu – yExN Rrp44 + DNA
2wp8 - yExN Rrp45, Ski6, Dis3
2ioc - hExN Trex1 N terminal
2nn6 – hExN Rrp41, Rrp45, Rrp42, Rrp40, Prp43, Rrp46, Mtr3, Csl4, Rrp4
Various ExN
1ir6, 2zxo, 2zxp, 2zxr – ExN Recj – Thermus thermophiles
1w0h – hExn Eri1 nuclease domain
1zbu - hExn Eri1
1zbh - hExn Eri1 (mutant) + DNA
1y97 – hExN Trex2
2o4g - mExN Trex1 + nucleotide – mouse
3mxj - mExN Trex1
2o4i, 3mxi, 3mxm - mExN Trex1 (mutant) + DNA
2oa8 - mExN Trex1 + DNA
3b6o, 3b6p - mExN Trex1 + ion inhibitor
2w45 – H4ExN alkaline - Herpesvirus 4
2w4b - H4ExN alkaline (mutant)
3e2v – yExN - yeast
