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Antithrombin

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{{STRUCTURE_1tb6| PDB=1tb6 | SIZE=400| SCENE= |right|CAPTION=Antithrombin complex with thrombin and heparin polysaccharide, [[1tb6]] }}
{{STRUCTURE_1tb6| PDB=1tb6 | SIZE=400| SCENE= |right|CAPTION=Antithrombin complex with thrombin and heparin polysaccharide, [[1tb6]] }}
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'''Antithrombin''' (AT) inactivates several enzymes of the coagulation cycle. A-AT contains 4 occupied glycosylation sites and is found in blood palsma. B-AT contains only 3 occupied glycosylation sites. AT-I refers to the absorption of thrombin to fibrin; AT-II and heparin interfere with the interactin of thrombin and fibrinogen; AT-III inactivates thrombin in plasma; AT-IV becomes activated during blood coagulation.
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'''Antithrombin''' (AT) inactivates several enzymes of the coagulation cycle. α-AT contains 4 occupied glycosylation sites and is found in blood palsma. β-AT contains only 3 occupied glycosylation sites. AT-I refers to the absorption of thrombin to fibrin; AT-II and heparin interfere with the interactin of thrombin and fibrinogen; AT-III inactivates thrombin in plasma; AT-IV becomes activated during blood coagulation.
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{{TOC limit|limit=2}}
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[[1ant]], [[2ant]] – hAT – human
[[1ant]], [[2ant]] – hAT – human
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[[1e05]] - ha-AT-III
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[[1e05]] - hα-AT-III
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[[1e04]] – hb-AT-III
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[[1e04]] – hβ-AT-III
[[1ath]], [[2znh]] – hAT-III
[[1ath]], [[2znh]] – hAT-III
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[[1azx]], [[1nq9]], [[3evj]] – hAT + heparin pentasaccharide
[[1azx]], [[1nq9]], [[3evj]] – hAT + heparin pentasaccharide
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[[1e03]] – ha-AT-III + heparin pentasaccharide
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[[1e03]] – hα-AT-III + heparin pentasaccharide
[[1dzh]] - hAT-III (mutant) + fluorescein
[[1dzh]] - hAT-III (mutant) + fluorescein

Revision as of 13:41, 26 October 2011

Template:STRUCTURE 1tb6

Antithrombin (AT) inactivates several enzymes of the coagulation cycle. α-AT contains 4 occupied glycosylation sites and is found in blood palsma. β-AT contains only 3 occupied glycosylation sites. AT-I refers to the absorption of thrombin to fibrin; AT-II and heparin interfere with the interactin of thrombin and fibrinogen; AT-III inactivates thrombin in plasma; AT-IV becomes activated during blood coagulation.

Contents

3D structures of antithrombin

1att – AT-III – bovine

1ant, 2ant – hAT – human

1e05 - hα-AT-III

1e04 – hβ-AT-III

1ath, 2znh – hAT-III

1dzg, 1oyh, 1t1f, 2beh, 2b4x, 2hij - hAT-III (mutant)

Antithrombin binary complexes

1azx, 1nq9, 3evj – hAT + heparin pentasaccharide

1e03 – hα-AT-III + heparin pentasaccharide

1dzh - hAT-III (mutant) + fluorescein

2gd4 - hAT-III (mutant) + coagulation factor X

1br8, 1jvq, 1lk6, 1r1l – hAT-III + peptide

Antithrombin ternary complexes

1sr5 - hAT-III + prothrombin + heparin heptasaccharide

1tb6 - hAT-III (mutant) + thrombin + heparin polysaccharide

2b5t - AT-III (mutant) + thrombin (mutant) + heparin polysaccharide

3kcg - hAT-III (mutant) + coagulation factor IXa + heparin pentasaccharide

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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