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Antithrombin
From Proteopedia
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{{STRUCTURE_1tb6| PDB=1tb6 | SIZE=400| SCENE= |right|CAPTION=Antithrombin complex with thrombin and heparin polysaccharide, [[1tb6]] }} | {{STRUCTURE_1tb6| PDB=1tb6 | SIZE=400| SCENE= |right|CAPTION=Antithrombin complex with thrombin and heparin polysaccharide, [[1tb6]] }} | ||
| - | '''Antithrombin''' (AT) inactivates several enzymes of the coagulation cycle. | + | '''Antithrombin''' (AT) inactivates several enzymes of the coagulation cycle. α-AT contains 4 occupied glycosylation sites and is found in blood palsma. β-AT contains only 3 occupied glycosylation sites. AT-I refers to the absorption of thrombin to fibrin; AT-II and heparin interfere with the interactin of thrombin and fibrinogen; AT-III inactivates thrombin in plasma; AT-IV becomes activated during blood coagulation. |
{{TOC limit|limit=2}} | {{TOC limit|limit=2}} | ||
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[[1ant]], [[2ant]] – hAT – human | [[1ant]], [[2ant]] – hAT – human | ||
| - | [[1e05]] - | + | [[1e05]] - hα-AT-III |
| - | [[1e04]] – | + | [[1e04]] – hβ-AT-III |
[[1ath]], [[2znh]] – hAT-III | [[1ath]], [[2znh]] – hAT-III | ||
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[[1azx]], [[1nq9]], [[3evj]] – hAT + heparin pentasaccharide | [[1azx]], [[1nq9]], [[3evj]] – hAT + heparin pentasaccharide | ||
| - | [[1e03]] – | + | [[1e03]] – hα-AT-III + heparin pentasaccharide |
[[1dzh]] - hAT-III (mutant) + fluorescein | [[1dzh]] - hAT-III (mutant) + fluorescein | ||
Revision as of 13:41, 26 October 2011
Antithrombin (AT) inactivates several enzymes of the coagulation cycle. α-AT contains 4 occupied glycosylation sites and is found in blood palsma. β-AT contains only 3 occupied glycosylation sites. AT-I refers to the absorption of thrombin to fibrin; AT-II and heparin interfere with the interactin of thrombin and fibrinogen; AT-III inactivates thrombin in plasma; AT-IV becomes activated during blood coagulation.
Contents |
3D structures of antithrombin
1att – AT-III – bovine
1e05 - hα-AT-III
1e04 – hβ-AT-III
1dzg, 1oyh, 1t1f, 2beh, 2b4x, 2hij - hAT-III (mutant)
Antithrombin binary complexes
1azx, 1nq9, 3evj – hAT + heparin pentasaccharide
1e03 – hα-AT-III + heparin pentasaccharide
1dzh - hAT-III (mutant) + fluorescein
2gd4 - hAT-III (mutant) + coagulation factor X
1br8, 1jvq, 1lk6, 1r1l – hAT-III + peptide
Antithrombin ternary complexes
1sr5 - hAT-III + prothrombin + heparin heptasaccharide
1tb6 - hAT-III (mutant) + thrombin + heparin polysaccharide
2b5t - AT-III (mutant) + thrombin (mutant) + heparin polysaccharide
3kcg - hAT-III (mutant) + coagulation factor IXa + heparin pentasaccharide
