2w3k
From Proteopedia
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[[Image:2w3k.png|left|200px]] | [[Image:2w3k.png|left|200px]] | ||
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===CRYSTAL STRUCTURE OF FXA IN COMPLEX WITH 4,4-DISUBSTITUTED PYRROLIDINE-1,2-DICARBOXAMIDE INHIBITOR 1=== | ===CRYSTAL STRUCTURE OF FXA IN COMPLEX WITH 4,4-DISUBSTITUTED PYRROLIDINE-1,2-DICARBOXAMIDE INHIBITOR 1=== | ||
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==See Also== | ==See Also== | ||
| - | *[[Factor Xa]] | + | *[[Factor Xa|Factor Xa]] |
==Reference== | ==Reference== | ||
Revision as of 04:50, 26 July 2012
Contents |
CRYSTAL STRUCTURE OF FXA IN COMPLEX WITH 4,4-DISUBSTITUTED PYRROLIDINE-1,2-DICARBOXAMIDE INHIBITOR 1
Template:ABSTRACT PUBMED 19231206
About this Structure
2w3k is a 2 chain structure of Factor Xa with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Van Huis CA, Casimiro-Garcia A, Bigge CF, Cody WL, Dudley DA, Filipski KJ, Heemstra RJ, Kohrt JT, Leadley RJ Jr, Narasimhan LS, McClanahan T, Mochalkin I, Pamment M, Peterson JT, Sahasrabudhe V, Schaum RP, Edmunds JJ. Exploration of 4,4-disubstituted pyrrolidine-1,2-dicarboxamides as potent, orally active Factor Xa inhibitors with extended duration of action. Bioorg Med Chem. 2009 Mar 15;17(6):2501-11. Epub 2009 Feb 3. PMID:19231206 doi:10.1016/j.bmc.2009.01.063
Categories: Coagulation factor Xa | Homo sapiens | Casimiro-Garcia, A. | Huis, C A.Van. | Mochalkin, I. | Zhang, E. | Blood clotting | Blood coagulation | Cleavage on pair of basic residue | Drug design | Egf-like domain | Fxa coagulation factor inhibitor | Gamma-carboxyglutamic acid | Glycoprotein | Hydrolase | Hydroxylation | Protease | Secreted | Serine protease | Zymogen
