1nvl

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[[Image:1nvl.png|left|200px]]
 
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{{STRUCTURE_1nvl| PDB=1nvl | SCENE= }}
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===RDC-refined NMR structure of bovine Acyl-coenzyme A Binding Protein, ACBP, in complex with palmitoyl-coenzyme A===
===RDC-refined NMR structure of bovine Acyl-coenzyme A Binding Protein, ACBP, in complex with palmitoyl-coenzyme A===
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==Function==
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[[http://www.uniprot.org/uniprot/ACBP_BOVIN ACBP_BOVIN]] Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor.<ref>PMID:11491287</ref>
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{{ABSTRACT_PUBMED_009100006}}
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==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:009100006</ref><references group="xtra"/>
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<ref group="xtra">PMID:009100006</ref><references group="xtra"/><references/>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Kragelund, B B.]]
[[Category: Kragelund, B B.]]

Revision as of 10:36, 16 April 2014

Template:STRUCTURE 1nvl

Contents

RDC-refined NMR structure of bovine Acyl-coenzyme A Binding Protein, ACBP, in complex with palmitoyl-coenzyme A

Function

[ACBP_BOVIN] Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor.[1]

About this Structure

1nvl is a 1 chain structure with sequence from Bos taurus. Full experimental information is available from OCA.

Reference

  • Vos S, de Jersey J, Martin JL. Crystal structure of Escherichia coli xanthine phosphoribosyltransferase. Biochemistry. 1997 Apr 8;36(14):4125-34. PMID:9100006 doi:10.1021/bi962640d
  1. ↑ van Aalten DM, Milne KG, Zou JY, Kleywegt GJ, Bergfors T, Ferguson MA, Knudsen J, Jones TA. Binding site differences revealed by crystal structures of Plasmodium falciparum and bovine acyl-CoA binding protein. J Mol Biol. 2001 May 25;309(1):181-92. PMID:11491287 doi:10.1006/jmbi.2001.4749

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OCA

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