Histone methyltransferase
From Proteopedia
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(New page: '''Histone methyltransferase''' (HMT) are histone-lysine N-methyltransferase (KHMT) and histone-arginine N-methyltransferase (RHMT) which catalyzes the transfer of methyl groups to ly...) |
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| + | {{STRUCTURE_3s7j| PDB=3s7j | SIZE=400| SCENE= |right|CAPTION=Human histone-lysine N-methyltrasferase Smyd2 complex with S-adenosyl methionine, [[3s7j]] }} | ||
| + | '''Histone methyltransferase''' (HMT) are histone-lysine N-methyltransferase (KHMT) and histone-arginine N-methyltransferase (RHMT) which catalyzes the transfer of methyl groups to lysine and arginine residues of histones. HMT use S-adenosyl methionine (SAM) or S-adenosyl homocysteine (SAH) as the methyl donor. | ||
| + | {{TOC limit|limit=2}} | ||
| - | + | == 3D Structures of histone methyltransferase == | |
[[1nw3]] – hHMT DOT1L – human | [[1nw3]] – hHMT DOT1L – human | ||
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[[3s7j]], [[3tg4]] - hKHMT Smyd2 + SAM | [[3s7j]], [[3tg4]] - hKHMT Smyd2 + SAM | ||
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| + | [[Category:Topic Page]] | ||
Revision as of 21:37, 29 September 2011
Histone methyltransferase (HMT) are histone-lysine N-methyltransferase (KHMT) and histone-arginine N-methyltransferase (RHMT) which catalyzes the transfer of methyl groups to lysine and arginine residues of histones. HMT use S-adenosyl methionine (SAM) or S-adenosyl homocysteine (SAH) as the methyl donor.
3D Structures of histone methyltransferase
1nw3 – hHMT DOT1L – human
2igq – hHMT-1 C terminal
Histone-lysine N-methyltransferase
2j8a – KHMT SET1 RRM domain – yeast
3s8s – hKHMT SETD1A RRM domain
3rib – hKHMT Smyd2 + SAH
3s7b - hKHMT Smyd2 + SAM + inhibitor
3s7d, 3s7f, 3tg5 - hKHMT Smyd2 + SAH + p53 peptide
3s7j, 3tg4 - hKHMT Smyd2 + SAM
