Casein kinase
From Proteopedia
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{{STRUCTURE_3mb6| PDB=3mb6 | SIZE=400| SCENE= |right|CAPTION=Human casein kinase catalytic subunit complex with inhibitor and sulfate ion, [[3mb6]] }} | {{STRUCTURE_3mb6| PDB=3mb6 | SIZE=400| SCENE= |right|CAPTION=Human casein kinase catalytic subunit complex with inhibitor and sulfate ion, [[3mb6]] }} | ||
| - | '''Casein kinase''' (CK) is a protein kinase which function as regulators of signal transduction. CK1 is a serine/threonine kinase with several members: | + | '''Casein kinase''' (CK) is a protein kinase which function as regulators of signal transduction. CK1 is a serine/threonine kinase with several members: α, β1, γ1, γ2, γ3, δ and ε. CK2 functions in cell cycle control, DNA repair and circadian rhythm regulation. CK2 is a tetramer with a pair of 2 subunits – the α subunit is the catalytic one and the β subunit is the regulatory one. |
{{TOC limit|limit=2}} | {{TOC limit|limit=2}} | ||
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===CK1=== | ===CK1=== | ||
| - | [[2c47]] – hCK1- | + | [[2c47]] – hCK1-γ2 – human |
| - | [[2chl]] - hCK1- | + | [[2chl]] - hCK1-γ3 |
| - | [[2cmw]] – hCK1- | + | [[2cmw]] – hCK1-γ1 + inhibitor |
| - | [[2izr]], [[2izs]], [[2izs]], [[2izu]] - hCK1- | + | [[2izr]], [[2izs]], [[2izs]], [[2izu]] - hCK1-γ3 + inhibitor |
| - | [[1cki]] – rCK1- | + | [[1cki]] – rCK1-δ (mutant) – rat |
| - | [[1ckj]] - rCK1- | + | [[1ckj]] - rCK1-δ (mutant) + WO4 |
[[1csn]] – yCK1 + MgATP – fission yeast | [[1csn]] – yCK1 + MgATP – fission yeast | ||
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===CK2 catalytic subunit=== | ===CK2 catalytic subunit=== | ||
| - | [[1pjk]] - hCK2 | + | [[1pjk]] - hCK2 α subunit |
| - | [[1na7]], [[3fwq]], [[3juh]] - hCK2 | + | [[1na7]], [[3fwq]], [[3juh]] - hCK2 α subunit (mutant) |
| - | [[3ofm]] - hCK2 | + | [[3ofm]] - hCK2 α’ subunit |
| - | [[2r7i]] - rCK2 | + | [[2r7i]] - rCK2 α subunit |
| - | [[1lpu]], [[1lr4]], [[1jam]] - mCK2 | + | [[1lpu]], [[1lr4]], [[1jam]] - mCK2 α subunit |
===CK2 catalytic subunit binary complex=== | ===CK2 catalytic subunit binary complex=== | ||
| - | [[2pvr]] - hCK2 | + | [[2pvr]] - hCK2 α subunit + sulfate |
| - | [[3rp0]] – hCK2 | + | [[3rp0]] – hCK2 α subunit + α’ subunit + ATP analog |
| - | [[3bqc]], [[3c13]] - hCK2 | + | [[3bqc]], [[3c13]] - hCK2 α subunit + emodin |
| - | [[1j91]] - mCK2 | + | [[1j91]] - mCK2 α subunit + ATP competitive inhibitor - maize |
| - | [[1lp4]] - mCK2 | + | [[1lp4]] - mCK2 α subunit + Mg-AMPPNP |
| - | [[3nsz]] - hCK2 | + | [[3nsz]] - hCK2 α subunit + AMPPN |
| - | [[1m2p]], [[1m2q]], [[1m2r]], [[1om1]], [[2oxd]], [[2oxx]], [[2oxy]], [[2qc6]], [[2pvh]], [[3fl5]], [[3kxg]], [[3kxh]], [[3kxm]], [[3kxn]], [[3pvg]] - mCK2 | + | [[1m2p]], [[1m2q]], [[1m2r]], [[1om1]], [[2oxd]], [[2oxx]], [[2oxy]], [[2qc6]], [[2pvh]], [[3fl5]], [[3kxg]], [[3kxh]], [[3kxm]], [[3kxn]], [[3pvg]] - mCK2 α subunit + inhibitor |
| - | [[3e3b]], [[2zjw]], [[3h30]], [[3mb6]], [[3mb7]], [[3nga]], [[3rps]], [[3pe1]], [[3pe2]], [[3amy]] - hCK2 | + | [[3e3b]], [[2zjw]], [[3h30]], [[3mb6]], [[3mb7]], [[3nga]], [[3rps]], [[3pe1]], [[3pe2]], [[3amy]] - hCK2 α subunit + inhibitor |
| - | [[2pvh]], [[2pvj]], [[2pvk]], [[2pvl]], [[2pvm]], [[2pvn]], [[3be9]] - mCK2 | + | [[2pvh]], [[2pvj]], [[2pvk]], [[2pvl]], [[2pvm]], [[2pvn]], [[3be9]] - mCK2 α subunit (mutant) + inhibitor |
===CK2 regulatory subunit=== | ===CK2 regulatory subunit=== | ||
| - | [[1qf8]], [[3eed]] – hCK2 | + | [[1qf8]], [[3eed]] – hCK2 β subunit |
| - | [[2r6m]] - rCK2 | + | [[2r6m]] - rCK2 β subunit |
| - | [[1rqf]] - CK2 | + | [[1rqf]] - CK2 β subunit + cyclin-dependent kinase peptide – ''Xenopus laevis'' |
===CK2 catalytic + regulatory subunits=== | ===CK2 catalytic + regulatory subunits=== | ||
| - | [[1jwh]] - hCK2 | + | [[1jwh]] - hCK2 α subunit + β subunit |
| - | [[1ds5]] - mCK2 | + | [[1ds5]] - mCK2 α subunit + β subunit peptide |
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 09:29, 26 October 2011
Casein kinase (CK) is a protein kinase which function as regulators of signal transduction. CK1 is a serine/threonine kinase with several members: α, β1, γ1, γ2, γ3, δ and ε. CK2 functions in cell cycle control, DNA repair and circadian rhythm regulation. CK2 is a tetramer with a pair of 2 subunits – the α subunit is the catalytic one and the β subunit is the regulatory one.
Contents |
3D Structures of casein kinase
CK1
2c47 – hCK1-γ2 – human
2chl - hCK1-γ3
2cmw – hCK1-γ1 + inhibitor
2izr, 2izs, 2izs, 2izu - hCK1-γ3 + inhibitor
1cki – rCK1-δ (mutant) – rat
1ckj - rCK1-δ (mutant) + WO4
1csn – yCK1 + MgATP – fission yeast
2csn, 1eh4 – yCK1 catalytic domain + inhibitor
CK2 catalytic subunit
1pjk - hCK2 α subunit
1na7, 3fwq, 3juh - hCK2 α subunit (mutant)
3ofm - hCK2 α’ subunit
2r7i - rCK2 α subunit
1lpu, 1lr4, 1jam - mCK2 α subunit
CK2 catalytic subunit binary complex
2pvr - hCK2 α subunit + sulfate
3rp0 – hCK2 α subunit + α’ subunit + ATP analog
3bqc, 3c13 - hCK2 α subunit + emodin
1j91 - mCK2 α subunit + ATP competitive inhibitor - maize
1lp4 - mCK2 α subunit + Mg-AMPPNP
3nsz - hCK2 α subunit + AMPPN
1m2p, 1m2q, 1m2r, 1om1, 2oxd, 2oxx, 2oxy, 2qc6, 2pvh, 3fl5, 3kxg, 3kxh, 3kxm, 3kxn, 3pvg - mCK2 α subunit + inhibitor
3e3b, 2zjw, 3h30, 3mb6, 3mb7, 3nga, 3rps, 3pe1, 3pe2, 3amy - hCK2 α subunit + inhibitor
2pvh, 2pvj, 2pvk, 2pvl, 2pvm, 2pvn, 3be9 - mCK2 α subunit (mutant) + inhibitor
CK2 regulatory subunit
2r6m - rCK2 β subunit
1rqf - CK2 β subunit + cyclin-dependent kinase peptide – Xenopus laevis
CK2 catalytic + regulatory subunits
1jwh - hCK2 α subunit + β subunit
1ds5 - mCK2 α subunit + β subunit peptide
