Neuropilin
From Proteopedia
(Difference between revisions)
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== 3D Structures of Neuropilin == | == 3D Structures of Neuropilin == | ||
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===NRP-1=== | ===NRP-1=== | ||
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[[2orx]] – rNRP-1 C1+C2 domains – rat | [[2orx]] – rNRP-1 C1+C2 domains – rat | ||
| - | [[2orz]] – rNRP-1 + tuftsin peptide | + | [[2orz]] – rNRP-1 + tuftsin peptide<br /> |
| + | [[4gz9]] - mNRP-1 A+B domain – mouse<br /> | ||
| + | [[4gza]] - mNRP-1 A+B domain + plexin A2 + semaphorin 3A | ||
===NRP-2=== | ===NRP-2=== | ||
Revision as of 12:24, 7 February 2013
Neuropilin (NRP) are neuronal receptors. NRP are co-receptors for semaphorins. There are 2 classes of NRP – NRP-1 and NRP-2. NRP-1 has high affinity for semaphorin-3A while NRP-2 has high affinity for semaphorin-3F.
3D Structures of Neuropilin
Update February 2013
NRP-1
1kex, 2qqi – hNRP-1 B domain – human
2qqm - hNRP-1 A+B domain
2qqn - hNRP-1 B domain + VEGF-blocking antibody
3i97 - hNRP-1 B domains + inhibitor
2orx – rNRP-1 C1+C2 domains – rat
2orz – rNRP-1 + tuftsin peptide
4gz9 - mNRP-1 A+B domain – mouse
4gza - mNRP-1 A+B domain + plexin A2 + semaphorin 3A
NRP-2
2qqj - hNRP-2 B domain
2qqo - hNRP-2 A+B domains
2qqk, 2qql - hNRP-2 A+B domains + semaphorin-blocking antibody
