1ido
From Proteopedia
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==Overview== | ==Overview== | ||
| - | We have determined the high resolution crystal structure of the A domain | + | We have determined the high resolution crystal structure of the A domain from the alpha chain of integrin CR3. The domain adopts a classic alpha/beta "Rossmann" fold and contains an unusual Mg2+ coordination site at its surface. One of the coordinating ligands is the glutamate side chain from another A domain molecule. We suggest that this site represents a general metal ion-dependent adhesion site (MIDAS) for binding protein ligands. We further propose that the beta subunits of integrins contain a MIDAS motif within a modified A domain. Our crystal structure will allow reliable models to be built for other members of the A domain superfamily and should facilitate development of novel adhesion modulatory drugs. |
==About this Structure== | ==About this Structure== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Lee, J | + | [[Category: Lee, J O.]] |
[[Category: Liddington, R.]] | [[Category: Liddington, R.]] | ||
[[Category: MG]] | [[Category: MG]] | ||
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[[Category: integrin]] | [[Category: integrin]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:10:47 2008'' |
Revision as of 11:10, 21 February 2008
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I-DOMAIN FROM INTEGRIN CR3, MG2+ BOUND
Overview
We have determined the high resolution crystal structure of the A domain from the alpha chain of integrin CR3. The domain adopts a classic alpha/beta "Rossmann" fold and contains an unusual Mg2+ coordination site at its surface. One of the coordinating ligands is the glutamate side chain from another A domain molecule. We suggest that this site represents a general metal ion-dependent adhesion site (MIDAS) for binding protein ligands. We further propose that the beta subunits of integrins contain a MIDAS motif within a modified A domain. Our crystal structure will allow reliable models to be built for other members of the A domain superfamily and should facilitate development of novel adhesion modulatory drugs.
About this Structure
1IDO is a Single protein structure of sequence from Homo sapiens with as ligand. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18)., Lee JO, Rieu P, Arnaout MA, Liddington R, Cell. 1995 Feb 24;80(4):631-8. PMID:7867070
Page seeded by OCA on Thu Feb 21 13:10:47 2008
