2xyv

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "2xyv" [edit=sysop:move=sysop])
Line 1: Line 1:
-
[[Image:2xyv.png|left|200px]]
+
==CRYSTAL STRUCTURE OF THE NSP16 NSP10 SARS CORONAVIRUS COMPLEX==
 +
<StructureSection load='2xyv' size='340' side='right' caption='[[2xyv]], [[Resolution|resolution]] 2.06&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[2xyv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus Sars coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XYV OCA]. <br>
 +
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
 +
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2d2d|2d2d]], [[2ahm|2ahm]], [[1p9t|1p9t]], [[1uk3|1uk3]], [[2xyr|2xyr]], [[1wof|1wof]], [[2amd|2amd]], [[2a5i|2a5i]], [[2v6n|2v6n]], [[2bx4|2bx4]], [[2acf|2acf]], [[2xyq|2xyq]], [[1uk4|1uk4]], [[1z1i|1z1i]], [[1o5s|1o5s]], [[2a5k|2a5k]], [[2c3s|2c3s]], [[1sxf|1sxf]], [[1uj1|1uj1]], [[1uk2|1uk2]], [[2amq|2amq]], [[2bx3|2bx3]], [[1pa5|1pa5]], [[1puk|1puk]], [[1uw7|1uw7]], [[1p76|1p76]], [[1q1x|1q1x]], [[2a5a|2a5a]], [[1ysy|1ysy]], [[1z1j|1z1j]]</td></tr>
 +
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
 +
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xyv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xyv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xyv RCSB], [http://www.ebi.ac.uk/pdbsum/2xyv PDBsum]</span></td></tr>
 +
<table>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Cellular and viral S-adenosylmethionine-dependent methyltransferases are involved in many regulated processes such as metabolism, detoxification, signal transduction, chromatin remodeling, nucleic acid processing, and mRNA capping. The Severe Acute Respiratory Syndrome coronavirus nsp16 protein is a S-adenosylmethionine-dependent (nucleoside-2'-O)-methyltransferase only active in the presence of its activating partner nsp10. We report the nsp10/nsp16 complex structure at 2.0 A resolution, which shows nsp10 bound to nsp16 through a approximately 930 A(2) surface area in nsp10. Functional assays identify key residues involved in nsp10/nsp16 association, and in RNA binding or catalysis, the latter likely through a SN2-like mechanism. We present two other crystal structures, the inhibitor Sinefungin bound in the S-adenosylmethionine binding pocket and the tighter complex nsp10(Y96F)/nsp16, providing the first structural insight into the regulation of RNA capping enzymes in +RNA viruses.
-
<!--
+
Crystal structure and functional analysis of the SARS-coronavirus RNA cap 2'-O-methyltransferase nsp10/nsp16 complex.,Decroly E, Debarnot C, Ferron F, Bouvet M, Coutard B, Imbert I, Gluais L, Papageorgiou N, Sharff A, Bricogne G, Ortiz-Lombardia M, Lescar J, Canard B PLoS Pathog. 2011 May;7(5):e1002059. Epub 2011 May 26. PMID:21637813<ref>PMID:21637813</ref>
-
The line below this paragraph, containing "STRUCTURE_2xyv", creates the "Structure Box" on the page.
+
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
-
or leave the SCENE parameter empty for the default display.
+
-
-->
+
-
{{STRUCTURE_2xyv| PDB=2xyv | SCENE= }}
+
-
===CRYSTAL STRUCTURE OF THE NSP16 NSP10 SARS CORONAVIRUS COMPLEX===
+
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-
 
+
</div>
-
 
+
== References ==
-
<!--
+
<references/>
-
The line below this paragraph, {{ABSTRACT_PUBMED_21637813}}, adds the Publication Abstract to the page
+
__TOC__
-
(as it appears on PubMed at http://www.pubmed.gov), where 21637813 is the PubMed ID number.
+
</StructureSection>
-
-->
+
-
{{ABSTRACT_PUBMED_21637813}}
+
-
 
+
-
==About this Structure==
+
-
[[2xyv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus Sars coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XYV OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:021637813</ref><references group="xtra"/>
+
[[Category: Sars coronavirus]]
[[Category: Sars coronavirus]]
[[Category: Bouvet, M.]]
[[Category: Bouvet, M.]]

Revision as of 07:48, 14 May 2014

CRYSTAL STRUCTURE OF THE NSP16 NSP10 SARS CORONAVIRUS COMPLEX

2xyv, resolution 2.06Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2xyv"
Views
Personal tools
Navigation
Toolbox