3qh9

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[[Image:3qh9.png|left|200px]]
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==Human Liprin-beta2 Coiled-Coil==
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<StructureSection load='3qh9' size='340' side='right' caption='[[3qh9]], [[Resolution|resolution]] 2.01&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3qh9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QH9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QH9 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene><br>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PPFIBP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qh9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qh9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qh9 RCSB], [http://www.ebi.ac.uk/pdbsum/3qh9 PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Liprins are a conserved family of scaffolding proteins important for the proper regulation and development of neuronal synapses. Humans have four liprin-alphas and two liprin-betas which all contain long coiled-coil domains followed by three tandem SAM domains. Complex interactions between the coiled-coil and SAM domains are thought to create liprin scaffolds, but the structural and biochemical properties of these domains remain largely uncharacterized. In this study we find that the human liprin-beta2 coiled-coil forms an extended dimer. Several protease-resistant subdomains within the liprin-beta1 and liprin-beta2 coiled-coils were also identified. A 2.0 A crystal structure of the central, protease-resistant core of the liprin-beta2 coiled-coil reveals a parallel helix orientation. These studies represent an initial step toward determining the overall architecture of liprin scaffolds and understanding the molecular basis for their synaptic functions.
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Crystal structure of the central coiled-coil domain from human liprin-beta2.,Stafford RL, Tang MY, Sawaya MR, Phillips ML, Bowie JU Biochemistry. 2011 May 10;50(18):3807-15. Epub 2011 Apr 15. PMID:21462929<ref>PMID:21462929</ref>
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The line below this paragraph, containing "STRUCTURE_3qh9", creates the "Structure Box" on the page.
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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{{STRUCTURE_3qh9| PDB=3qh9 | SCENE= }}
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===Human Liprin-beta2 Coiled-Coil===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_21462929}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 21462929 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_21462929}}
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==About this Structure==
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[[3qh9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QH9 OCA].
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==Reference==
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<ref group="xtra">PMID:021462929</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Bowie, J U.]]
[[Category: Bowie, J U.]]

Revision as of 05:26, 4 June 2014

Human Liprin-beta2 Coiled-Coil

3qh9, resolution 2.01Å

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