This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3sp4
From Proteopedia
| Line 1: | Line 1: | ||
| - | [[Image:3sp4.png|left|200px]] | ||
| - | |||
| - | <!-- | ||
| - | The line below this paragraph, containing "STRUCTURE_3sp4", creates the "Structure Box" on the page. | ||
| - | You may change the PDB parameter (which sets the PDB file loaded into the applet) | ||
| - | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | ||
| - | or leave the SCENE parameter empty for the default display. | ||
| - | --> | ||
{{STRUCTURE_3sp4| PDB=3sp4 | SCENE= }} | {{STRUCTURE_3sp4| PDB=3sp4 | SCENE= }} | ||
| - | |||
===Crystal structure of aprataxin ortholog Hnt3 from Schizosaccharomyces pombe=== | ===Crystal structure of aprataxin ortholog Hnt3 from Schizosaccharomyces pombe=== | ||
| + | {{ABSTRACT_PUBMED_21984208}} | ||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/APTX_SCHPO APTX_SCHPO]] DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined (By similarity). | ||
==About this Structure== | ==About this Structure== | ||
| - | [[3sp4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | [[3sp4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe_972h- Schizosaccharomyces pombe 972h-]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SP4 OCA]. |
| - | [[Category: Schizosaccharomyces pombe]] | + | |
| + | ==Reference== | ||
| + | <ref group="xtra">PMID:021984208</ref><references group="xtra"/><references/> | ||
| + | [[Category: Schizosaccharomyces pombe 972h-]] | ||
[[Category: Ding, J.]] | [[Category: Ding, J.]] | ||
[[Category: Dou, C.]] | [[Category: Dou, C.]] | ||
Revision as of 10:46, 3 July 2013
Contents |
Crystal structure of aprataxin ortholog Hnt3 from Schizosaccharomyces pombe
Template:ABSTRACT PUBMED 21984208
Function
[APTX_SCHPO] DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined (By similarity).
About this Structure
3sp4 is a 2 chain structure with sequence from Schizosaccharomyces pombe 972h-. Full crystallographic information is available from OCA.
Reference
- Gong Y, Zhu D, Ding J, Dou CN, Ren X, Gu L, Jiang T, Wang DC. Crystal structures of aprataxin ortholog Hnt3 reveal the mechanism for reversal of 5'-adenylated DNA. Nat Struct Mol Biol. 2011 Oct 9;18(11):1297-9. doi: 10.1038/nsmb.2145. PMID:21984208 doi:10.1038/nsmb.2145
