3l85

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[[Image:3l85.png|left|200px]]
 
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{{STRUCTURE_3l85| PDB=3l85 | SCENE= }}
{{STRUCTURE_3l85| PDB=3l85 | SCENE= }}
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===Crystal structure of human NUDT5 complexed with 8-oxo-dGMP===
===Crystal structure of human NUDT5 complexed with 8-oxo-dGMP===
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{{ABSTRACT_PUBMED_21768126}}
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==Function==
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[[http://www.uniprot.org/uniprot/NUDT5_HUMAN NUDT5_HUMAN]] Hydrolyzes with similar activities ADP-ribose ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP. Can also hydrolyze other nucleotide sugars with low activity.<ref>PMID:17052728</ref>
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{{ABSTRACT_PUBMED_21768126}}
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==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:021768126</ref><references group="xtra"/>
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<ref group="xtra">PMID:021768126</ref><references group="xtra"/><references/>
[[Category: ADP-ribose diphosphatase]]
[[Category: ADP-ribose diphosphatase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]

Revision as of 18:19, 19 June 2013

Template:STRUCTURE 3l85

Contents

Crystal structure of human NUDT5 complexed with 8-oxo-dGMP

Template:ABSTRACT PUBMED 21768126

Function

[NUDT5_HUMAN] Hydrolyzes with similar activities ADP-ribose ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP. Can also hydrolyze other nucleotide sugars with low activity.[1]

About this Structure

3l85 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Arimori T, Tamaoki H, Nakamura T, Kamiya H, Ikemizu S, Takagi Y, Ishibashi T, Harashima H, Sekiguchi M, Yamagata Y. Diverse substrate recognition and hydrolysis mechanisms of human NUDT5. Nucleic Acids Res. 2011 Nov 1;39(20):8972-83. Epub 2011 Jul 17. PMID:21768126 doi:10.1093/nar/gkr575
  1. Zha M, Zhong C, Peng Y, Hu H, Ding J. Crystal structures of human NUDT5 reveal insights into the structural basis of the substrate specificity. J Mol Biol. 2006 Dec 15;364(5):1021-33. Epub 2006 Oct 3. PMID:17052728 doi:10.1016/j.jmb.2006.09.078

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