User:Udayan Shevade/Sandbox1
From Proteopedia
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T-antigen consists of an N-terminal J domain, a central origin-binding domain, and a C-terminal helicase domain <ref name="A"/>. | T-antigen consists of an N-terminal J domain, a central origin-binding domain, and a C-terminal helicase domain <ref name="A"/>. | ||
| - | <StructureSection load='1tbd' size=' | + | <StructureSection load='1tbd' size='350' side='right' caption='The origin binding domain of SV40 T antigen (PDB entry [[1tbd]])'> |
==== The Origin Binding Domain ==== | ==== The Origin Binding Domain ==== | ||
Revision as of 03:29, 11 November 2011
Contents |
SV40 Large T Antigen
Introduction
The SV40 large T antigen is a multifunctional regulatory protein encoded by Simian Virus 40, belonging to the AAA+ family of helicases [1]. It is responsible for initiation of DNA replication, regulation of transcription and alteration of the host cell cycle to promote infectivity. Large T antigen is an early gene product of SV40 and is translated via differential mRNA splicing.
Structure
T-antigen consists of an N-terminal J domain, a central origin-binding domain, and a C-terminal helicase domain [1].
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