Retinoblastoma protein
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
{{STRUCTURE_1o9k| PDB=1o9k | SCENE= }} | {{STRUCTURE_1o9k| PDB=1o9k | SCENE= }} | ||
| - | + | ==Retinoblastoma Protein (pRB)== | |
| + | The Retinoblastoma protein (pRB) is a tumor suppressor protein that prevents excessive cell growth. If not mutated, it is present in our cells and blocks the growth of dysfunctional cells between the G1 and S phase of the cell cycle before they can undergo DNA replication. pRB regulates the function of cyclin and cyclin dependent kinase complexes which are needed for the cell to proceed cell growth. Retinoblastoma protein is dependent on the transcription factor E2F, which is bound to pRB's active site when it is dephosphorylated. In viral cells, and tumorous cells pRB is dysfunctional or completely lost. | ||
Revision as of 22:56, 11 November 2011
| |||||||||
| 1o9k, resolution 2.60Å () | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Related: | 1pjm, 1n4m, 1h24, 1ad6, 1h25, 1gh6, 1gux, 2aze | ||||||||
| |||||||||
| |||||||||
| Resources: | FirstGlance, OCA, RCSB, PDBsum | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
Retinoblastoma Protein (pRB)
The Retinoblastoma protein (pRB) is a tumor suppressor protein that prevents excessive cell growth. If not mutated, it is present in our cells and blocks the growth of dysfunctional cells between the G1 and S phase of the cell cycle before they can undergo DNA replication. pRB regulates the function of cyclin and cyclin dependent kinase complexes which are needed for the cell to proceed cell growth. Retinoblastoma protein is dependent on the transcription factor E2F, which is bound to pRB's active site when it is dephosphorylated. In viral cells, and tumorous cells pRB is dysfunctional or completely lost.
Proteopedia Page Contributors and Editors (what is this?)
Yvonne Alva, Michal Harel, Joel L. Sussman, Alexander Berchansky
