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Sandbox 47
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== '''Function''' == | == '''Function''' == | ||
Most lipases act at a specific position on the glycerol backbone of the lipid substrate.<ref>"Lipase". Wikipedia: The Free Encyclopedia. 6 Nov 2011 [http://en.wikipedia.org/wiki/Lipase]</ref> Bile salts aid lipase in fat hydrolysis by increasing the surface area of fats. | Most lipases act at a specific position on the glycerol backbone of the lipid substrate.<ref>"Lipase". Wikipedia: The Free Encyclopedia. 6 Nov 2011 [http://en.wikipedia.org/wiki/Lipase]</ref> Bile salts aid lipase in fat hydrolysis by increasing the surface area of fats. | ||
| - | Unlike many proteases, pancreatic lipase is secreted in its final form. However, it is only active in the presence of <scene name='Sandbox_47/Colipase/1'>colipase</scene> in the duodenum. <scene name='Sandbox_47/Colipasecontacts/2'>colipase contacts</scene> Colipase is also secreted in the pancreas, but in its inactive form, procolipase, which is activated by trypsin in the intestinal lumen. Colipase prevent the inhibitory effect of bile salts on the lipase-catalyzed intraduodenal hydrolysis of dietary long-chain triglycerides.<ref>"Colipase". Wikipedia: The Free Encyclopedia. 5 July 2011 [http://en.wikipedia.org/wiki/Colipase]</ref> | + | Unlike many proteases, pancreatic lipase is secreted in its final form. However, it is only active in the presence of <scene name='Sandbox_47/Colipase/1'>colipase</scene> in the duodenum. <scene name='Sandbox_47/Colipasecontacts/2'>colipase contacts</scene> <ref>"van Tilbeurgh H, Sarda L, Verger R, Cambillau C. 1992. Structure of the pancreatic lipase-procolipase complex. Nature 359: 159-162. </ref> |
| + | Colipase is also secreted in the pancreas, but in its inactive form, procolipase, which is activated by trypsin in the intestinal lumen. Colipase prevent the inhibitory effect of bile salts on the lipase-catalyzed intraduodenal hydrolysis of dietary long-chain triglycerides.<ref>"Colipase". Wikipedia: The Free Encyclopedia. 5 July 2011 [http://en.wikipedia.org/wiki/Colipase]</ref> | ||
Revision as of 05:56, 12 November 2011
| Please do NOT make changes to this Sandbox. Sandboxes 30-60 are reserved for use by Biochemistry 410 & 412 at Messiah College taught by Dr. Hannah Tims during Fall 2012 and Spring 2013. |
Lipase
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