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1s9q

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[[Image:1s9q.png|left|200px]]
 
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{{STRUCTURE_1s9q| PDB=1s9q | SCENE= }}
{{STRUCTURE_1s9q| PDB=1s9q | SCENE= }}
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===crystal structure of the ligand-binding domain of the estrogen-related receptor gamma in complex with 4-hydroxytamoxifen===
===crystal structure of the ligand-binding domain of the estrogen-related receptor gamma in complex with 4-hydroxytamoxifen===
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{{ABSTRACT_PUBMED_15161930}}
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==Function==
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[[http://www.uniprot.org/uniprot/ERR3_MOUSE ERR3_MOUSE]] Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements.<ref>PMID:10428842</ref>
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(as it appears on PubMed at http://www.pubmed.gov), where 15161930 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15161930}}
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==About this Structure==
==About this Structure==
[[1s9q]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S9Q OCA].
[[1s9q]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S9Q OCA].
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==See Also==
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*[[Estrogen-related receptor|Estrogen-related receptor]]
==Reference==
==Reference==
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<ref group="xtra">PMID:015161930</ref><references group="xtra"/>
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<ref group="xtra">PMID:015161930</ref><references group="xtra"/><references/>
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Flaig, R.]]
[[Category: Flaig, R.]]

Revision as of 08:22, 23 April 2014

Template:STRUCTURE 1s9q

Contents

crystal structure of the ligand-binding domain of the estrogen-related receptor gamma in complex with 4-hydroxytamoxifen

Template:ABSTRACT PUBMED 15161930

Function

[ERR3_MOUSE] Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements.[1]

About this Structure

1s9q is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

See Also

Reference

  • Greschik H, Flaig R, Renaud JP, Moras D. Structural basis for the deactivation of the estrogen-related receptor gamma by diethylstilbestrol or 4-hydroxytamoxifen and determinants of selectivity. J Biol Chem. 2004 Aug 6;279(32):33639-46. Epub 2004 May 24. PMID:15161930 doi:http://dx.doi.org/10.1074/jbc.M402195200
  1. ↑ Hong H, Yang L, Stallcup MR. Hormone-independent transcriptional activation and coactivator binding by novel orphan nuclear receptor ERR3. J Biol Chem. 1999 Aug 6;274(32):22618-26. PMID:10428842

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