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1ye6

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[[Image:1ye6.png|left|200px]]
 
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{{STRUCTURE_1ye6| PDB=1ye6 | SCENE= }}
{{STRUCTURE_1ye6| PDB=1ye6 | SCENE= }}
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===Crystal structure of the Lys-274 to Arg mutant of Candida tenuis xylose reductase (AKR2B5) bound to NADP+===
===Crystal structure of the Lys-274 to Arg mutant of Candida tenuis xylose reductase (AKR2B5) bound to NADP+===
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{{ABSTRACT_PUBMED_15670843}}
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==Function==
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[[http://www.uniprot.org/uniprot/XYL1_CANTE XYL1_CANTE]] Reduces D-xylose into xylitol. Has a preference for NADPH, but can also utilize NADH as cosubstrate.
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{{ABSTRACT_PUBMED_15670843}}
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==About this Structure==
==About this Structure==
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[[1ye6]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Candida_tenuis Candida tenuis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YE6 OCA].
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[[1ye6]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_10573 Atcc 10573]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YE6 OCA].
==Reference==
==Reference==
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<ref group="xtra">PMID:015670843</ref><references group="xtra"/>
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<ref group="xtra">PMID:015670843</ref><references group="xtra"/><references/>
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[[Category: Candida tenuis]]
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[[Category: Atcc 10573]]
[[Category: Leitgeb, S.]]
[[Category: Leitgeb, S.]]
[[Category: Nidetzky, B.]]
[[Category: Nidetzky, B.]]

Revision as of 08:40, 23 April 2014

Template:STRUCTURE 1ye6

Contents

Crystal structure of the Lys-274 to Arg mutant of Candida tenuis xylose reductase (AKR2B5) bound to NADP+

Template:ABSTRACT PUBMED 15670843

Function

[XYL1_CANTE] Reduces D-xylose into xylitol. Has a preference for NADPH, but can also utilize NADH as cosubstrate.

About this Structure

1ye6 is a 4 chain structure with sequence from Atcc 10573. Full crystallographic information is available from OCA.

Reference

  • Leitgeb S, Petschacher B, Wilson DK, Nidetzky B. Fine tuning of coenzyme specificity in family 2 aldo-keto reductases revealed by crystal structures of the Lys-274-->Arg mutant of Candida tenuis xylose reductase (AKR2B5) bound to NAD+ and NADP+. FEBS Lett. 2005 Jan 31;579(3):763-7. PMID:15670843 doi:10.1016/j.febslet.2004.12.063

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