1ozq

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[[Image:1ozq.png|left|200px]]
 
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{{STRUCTURE_1ozq| PDB=1ozq | SCENE= }}
{{STRUCTURE_1ozq| PDB=1ozq | SCENE= }}
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===CRYSTAL STRUCTURE OF THE MUTATED TRNA-GUANINE TRANSGLYCOSYLASE (TGT)Y106F COMPLEXED WITH PREQ1===
===CRYSTAL STRUCTURE OF THE MUTATED TRNA-GUANINE TRANSGLYCOSYLASE (TGT)Y106F COMPLEXED WITH PREQ1===
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{{ABSTRACT_PUBMED_14523925}}
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==Function==
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[[http://www.uniprot.org/uniprot/TGT_ZYMMO TGT_ZYMMO]] Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).[HAMAP-Rule:MF_00168]
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==About this Structure==
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The line below this paragraph, {{ABSTRACT_PUBMED_14523925}}, adds the Publication Abstract to the page
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[[1ozq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"achromobacter_anaerobium"_(sic)_shimwell_1937 "achromobacter anaerobium" (sic) shimwell 1937]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OZQ OCA].
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(as it appears on PubMed at http://www.pubmed.gov), where 14523925 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14523925}}
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==About this Structure==
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==See Also==
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[[1ozq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Zymomonas_mobilis Zymomonas mobilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OZQ OCA].
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*[[TRNA-guanine transglycosylase|TRNA-guanine transglycosylase]]
==Reference==
==Reference==
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<ref group="xtra">PMID:014523925</ref><ref group="xtra">PMID:012954331</ref><references group="xtra"/>
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<ref group="xtra">PMID:014523925</ref><references group="xtra"/><references/>
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[[Category: Zymomonas mobilis]]
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[[Category: TRNA-guanine transglycosylase]]
[[Category: TRNA-guanine transglycosylase]]
[[Category: Brenk, R.]]
[[Category: Brenk, R.]]

Revision as of 10:55, 16 April 2014

Template:STRUCTURE 1ozq

Contents

CRYSTAL STRUCTURE OF THE MUTATED TRNA-GUANINE TRANSGLYCOSYLASE (TGT)Y106F COMPLEXED WITH PREQ1

Template:ABSTRACT PUBMED 14523925

Function

[TGT_ZYMMO] Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).[HAMAP-Rule:MF_00168]

About this Structure

1ozq is a 1 chain structure with sequence from "achromobacter_anaerobium"_(sic)_shimwell_1937 "achromobacter anaerobium" (sic) shimwell 1937. Full crystallographic information is available from OCA.

See Also

Reference

  • Brenk R, Stubbs MT, Heine A, Reuter K, Klebe G. Flexible adaptations in the structure of the tRNA-modifying enzyme tRNA-guanine transglycosylase and their implications for substrate selectivity, reaction mechanism and structure-based drug design. Chembiochem. 2003 Oct 6;4(10):1066-77. PMID:14523925 doi:10.1002/cbic.200300644

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OCA

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