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1z5p

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[[Image:1z5p.png|left|200px]]
 
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{{STRUCTURE_1z5p| PDB=1z5p | SCENE= }}
{{STRUCTURE_1z5p| PDB=1z5p | SCENE= }}
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===Crystal structure of MTA/AdoHcy nucleosidase with a ligand-free purine binding site===
===Crystal structure of MTA/AdoHcy nucleosidase with a ligand-free purine binding site===
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{{ABSTRACT_PUBMED_16109423}}
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==Function==
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[[http://www.uniprot.org/uniprot/MTNN_ECOLI MTNN_ECOLI]] Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively. Can also use 5'-isobutylthioadenosine, 5'-n-butylthioadenosine, S-adenosyl-D-homocysteine, decarboxylated adenosylhomocysteine, deaminated adenosylhomocysteine and S-2-aza-adenosylhomocysteine as substrates.[HAMAP-Rule:MF_01684]
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{{ABSTRACT_PUBMED_16109423}}
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==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:016109423</ref><references group="xtra"/>
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<ref group="xtra">PMID:016109423</ref><references group="xtra"/><references/>
[[Category: Adenosylhomocysteine nucleosidase]]
[[Category: Adenosylhomocysteine nucleosidase]]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]

Revision as of 08:53, 23 April 2014

Template:STRUCTURE 1z5p

Contents

Crystal structure of MTA/AdoHcy nucleosidase with a ligand-free purine binding site

Template:ABSTRACT PUBMED 16109423

Function

[MTNN_ECOLI] Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively. Can also use 5'-isobutylthioadenosine, 5'-n-butylthioadenosine, S-adenosyl-D-homocysteine, decarboxylated adenosylhomocysteine, deaminated adenosylhomocysteine and S-2-aza-adenosylhomocysteine as substrates.[HAMAP-Rule:MF_01684]

About this Structure

1z5p is a 1 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

  • Lee JE, Smith GD, Horvatin C, Huang DJ, Cornell KA, Riscoe MK, Howell PL. Structural snapshots of MTA/AdoHcy nucleosidase along the reaction coordinate provide insights into enzyme and nucleoside flexibility during catalysis. J Mol Biol. 2005 Sep 23;352(3):559-74. PMID:16109423 doi:http://dx.doi.org/10.1016/j.jmb.2005.07.027

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OCA

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