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1jpv
From Proteopedia
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{{STRUCTURE_1jpv| PDB=1jpv | SCENE= }} | {{STRUCTURE_1jpv| PDB=1jpv | SCENE= }} | ||
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===Crystal Structure of 5'-deoxy-5'-methylthioadenosine phosphorylase complexed with SO4=== | ===Crystal Structure of 5'-deoxy-5'-methylthioadenosine phosphorylase complexed with SO4=== | ||
| + | {{ABSTRACT_PUBMED_11489901}} | ||
| - | + | ==Function== | |
| - | + | [[http://www.uniprot.org/uniprot/MTAP_SULSO MTAP_SULSO]] Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.<ref>PMID:15819883</ref> | |
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==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:011489901</ref><references group="xtra"/> | + | <ref group="xtra">PMID:011489901</ref><references group="xtra"/><references/> |
[[Category: S-methyl-5'-thioadenosine phosphorylase]] | [[Category: S-methyl-5'-thioadenosine phosphorylase]] | ||
[[Category: Sulfolobus solfataricus]] | [[Category: Sulfolobus solfataricus]] | ||
Revision as of 10:46, 16 April 2014
Contents |
Crystal Structure of 5'-deoxy-5'-methylthioadenosine phosphorylase complexed with SO4
Template:ABSTRACT PUBMED 11489901
Function
[MTAP_SULSO] Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.[1]
About this Structure
1jpv is a 3 chain structure with sequence from Sulfolobus solfataricus. Full crystallographic information is available from OCA.
Reference
- Appleby TC, Mathews II, Porcelli M, Cacciapuoti G, Ealick SE. Three-dimensional structure of a hyperthermophilic 5'-deoxy-5'-methylthioadenosine phosphorylase from Sulfolobus solfataricus. J Biol Chem. 2001 Oct 19;276(42):39232-42. Epub 2001 Aug 6. PMID:11489901 doi:http://dx.doi.org/10.1074/jbc.M105694200
- ↑ Cacciapuoti G, Forte S, Moretti MA, Brio A, Zappia V, Porcelli M. A novel hyperthermostable 5'-deoxy-5'-methylthioadenosine phosphorylase from the archaeon Sulfolobus solfataricus. FEBS J. 2005 Apr;272(8):1886-99. PMID:15819883 doi:http://dx.doi.org/10.1111/j.1742-4658.2005.04619.x
