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1s3z

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[[Image:1s3z.png|left|200px]]
 
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{{STRUCTURE_1s3z| PDB=1s3z | SCENE= }}
{{STRUCTURE_1s3z| PDB=1s3z | SCENE= }}
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===Aminoglycoside N-Acetyltransferase AAC(6')-Iy in Complex with CoA and Ribostamycin===
===Aminoglycoside N-Acetyltransferase AAC(6')-Iy in Complex with CoA and Ribostamycin===
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{{ABSTRACT_PUBMED_15123251}}
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==Function==
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[[http://www.uniprot.org/uniprot/Q9R381_SALEN Q9R381_SALEN]] Catalyzes the transfer of an acetyl group from acetyl-CoA to the 6'-amino group of aminoglycoside molecules conferring resistance to antibiotics containing the purpurosamine ring including amikacin, tobramycin, dibekacin and ribostamycin. Able to acetylate eukaryotic histone proteins.<ref>PMID:10542165</ref> <ref>PMID:15123251</ref>
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{{ABSTRACT_PUBMED_15123251}}
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==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:015123251</ref><references group="xtra"/>
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<ref group="xtra">PMID:015123251</ref><references group="xtra"/><references/>
[[Category: Salmonella enterica subsp. enterica serovar enteritidis]]
[[Category: Salmonella enterica subsp. enterica serovar enteritidis]]
[[Category: Blachard, J S.]]
[[Category: Blachard, J S.]]

Revision as of 08:50, 23 April 2014

Template:STRUCTURE 1s3z

Contents

Aminoglycoside N-Acetyltransferase AAC(6')-Iy in Complex with CoA and Ribostamycin

Template:ABSTRACT PUBMED 15123251

Function

[Q9R381_SALEN] Catalyzes the transfer of an acetyl group from acetyl-CoA to the 6'-amino group of aminoglycoside molecules conferring resistance to antibiotics containing the purpurosamine ring including amikacin, tobramycin, dibekacin and ribostamycin. Able to acetylate eukaryotic histone proteins.[1] [2]

About this Structure

1s3z is a 2 chain structure with sequence from Salmonella enterica subsp. enterica serovar enteritidis. Full crystallographic information is available from OCA.

Reference

  • Vetting MW, Magnet S, Nieves E, Roderick SL, Blanchard JS. A bacterial acetyltransferase capable of regioselective N-acetylation of antibiotics and histones. Chem Biol. 2004 Apr;11(4):565-73. PMID:15123251 doi:10.1016/j.chembiol.2004.03.017
  1. ↑ Magnet S, Courvalin P, Lambert T. Activation of the cryptic aac(6')-Iy aminoglycoside resistance gene of Salmonella by a chromosomal deletion generating a transcriptional fusion. J Bacteriol. 1999 Nov;181(21):6650-5. PMID:10542165
  2. ↑ Vetting MW, Magnet S, Nieves E, Roderick SL, Blanchard JS. A bacterial acetyltransferase capable of regioselective N-acetylation of antibiotics and histones. Chem Biol. 2004 Apr;11(4):565-73. PMID:15123251 doi:10.1016/j.chembiol.2004.03.017

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