3p2x

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'''Unreleased structure'''
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[[Image:3p2x.jpg|left|200px]]
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The entry 3p2x is ON HOLD until Nov 18 2012
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{{STRUCTURE_3p2x| PDB=3p2x | SCENE= }}
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Authors: Hua, Q.X., Wan, Z.L., Huang, K., Hu, S.Q., Phillip, N.F., Jia, W.H., Whittingham, J., Dodson, G.G., Katsoyannis, P.G., Weiss, M.A.
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===Insulin fibrillation is the Janus face of induced fit. A chiaral clamp stabilizes the native state at the expense of activity===
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Description: Insulin fibrillation is the Janus face of induced fit. A chiaral clamp stabilizes the native state at the expense of activity
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{{ABSTRACT_PUBMED_15794638}}
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==About this Structure==
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[[3p2x]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P2X OCA].
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==Reference==
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<ref group="xtra">PMID:015794638</ref><ref group="xtra">PMID:014596591</ref><ref group="xtra">PMID:015610006</ref><ref group="xtra">PMID:002905485</ref><ref group="xtra">PMID:002648161</ref><references group="xtra"/>
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[[Category: Dodson, G G.]]
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[[Category: Hu, S Q.]]
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[[Category: Hua, Q X.]]
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[[Category: Huang, K.]]
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[[Category: Jia, W H.]]
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[[Category: Katsoyannis, P G.]]
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[[Category: Phillip, N F.]]
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[[Category: Wan, Z L.]]
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[[Category: Weiss, M A.]]
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[[Category: Whittingham, J.]]
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[[Category: Global health]]
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[[Category: Hormone]]
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[[Category: Insulin fibrillation]]
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[[Category: Long-acting insulin analog]]
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[[Category: Receptor binding protein engineering]]
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[[Category: Zinc-binding site]]

Revision as of 19:12, 23 November 2011

Image:3p2x.jpg

Template:STRUCTURE 3p2x

Insulin fibrillation is the Janus face of induced fit. A chiaral clamp stabilizes the native state at the expense of activity

Template:ABSTRACT PUBMED 15794638

About this Structure

3p2x is a 4 chain structure. Full crystallographic information is available from OCA.

Reference

  • Wan ZL, Huang K, Xu B, Hu SQ, Wang S, Chu YC, Katsoyannis PG, Weiss MA. Diabetes-associated mutations in human insulin: crystal structure and photo-cross-linking studies of a-chain variant insulin Wakayama. Biochemistry. 2005 Apr 5;44(13):5000-16. PMID:15794638 doi:10.1021/bi047585k
  • Wan ZL, Xu B, Chu YC, Katsoyannis PG, Weiss MA. Crystal structure of allo-Ile(A2)-insulin, an inactive chiral analogue: implications for the mechanism of receptor binding. Biochemistry. 2003 Nov 11;42(44):12770-83. PMID:14596591 doi:10.1021/bi034430o
  • Wan Z, Xu B, Huang K, Chu YC, Li B, Nakagawa SH, Qu Y, Hu SQ, Katsoyannis PG, Weiss MA. Enhancing the activity of insulin at the receptor interface: crystal structure and photo-cross-linking of A8 analogues. Biochemistry. 2004 Dec 28;43(51):16119-33. PMID:15610006 doi:10.1021/bi048223f
  • Baker EN, Blundell TL, Cutfield JF, Cutfield SM, Dodson EJ, Dodson GG, Hodgkin DM, Hubbard RE, Isaacs NW, Reynolds CD, et al.. The structure of 2Zn pig insulin crystals at 1.5 A resolution. Philos Trans R Soc Lond B Biol Sci. 1988 Jul 6;319(1195):369-456. PMID:2905485
  • Derewenda U, Derewenda Z, Dodson EJ, Dodson GG, Reynolds CD, Smith GD, Sparks C, Swenson D. Phenol stabilizes more helix in a new symmetrical zinc insulin hexamer. Nature. 1989 Apr 13;338(6216):594-6. PMID:2648161 doi:http://dx.doi.org/10.1038/338594a0

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