Anthrax Lethal Factor

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'''Pertussis Toxins''' (PT) is a protein-based exotoxin and major virulence factor produced by the bacterium [http://en.wikipedia.org/wiki/Bordetella_pertussis ''Bordetella pertussis''].<ref name=Hazes>PMID: 8637000</ref> PT causes [http://en.wikipedia.org/wiki/Whooping_cough pertussis], which is also known at [http://www.youtube.com/watch?v=1PajbAKd8Kg whooping cough] and is highly contagious bacterial disease. The disease is caused by the bacterium colonizing the respiratory tract where it then establishes an infection.<ref name=Carbonetti>PMID: 14573656</ref> This disease had been characterized by severe coughing that can last up to six weeks and in some countries lasting nearly 100 days.<ref name=Carbonetti>PMID: 17418639</ref>It has been documented in some cases that PT can cause [http://en.wikipedia.org/wiki/Subconjunctival_hemorrhage subconjunctival hemorrhages], [http://en.wikipedia.org/wiki/Rib_fracture rib fractures], [http://en.wikipedia.org/wiki/Hernias hernias], fainting and [http://en.wikipedia.org/wiki/Vertebral_artery_dissection vertebral artery dissection].<ref name=cornia>PMID: 20736473</ref>

As of 2010, the worldwide incidence of whooping cough has been estimated to 48.5 million cases and nearly 295,000 deaths per year.<ref name=Bettiol>PMID: 20091541</ref> With that in mind, whooping cough can affect people of any age; however, before vaccines were available the disease was most common in infants and young children but now children are immunized and the high percentage of cases are seen among adolescents.

'''Pertussis Toxins''' (PT) is a protein-based exotoxin and major virulence factor produced by the bacterium [http://en.wikipedia.org/wiki/Bordetella_pertussis ''Bordetella pertussis''].<ref name=Hazes>PMID: 8637000</ref> PT causes [http://en.wikipedia.org/wiki/Whooping_cough pertussis], which is also known at [http://www.youtube.com/watch?v=1PajbAKd8Kg whooping cough] and is highly contagious bacterial disease. The disease is caused by the bacterium colonizing the respiratory tract where it then establishes an infection.<ref name=Carbonetti>PMID: 14573656</ref> This disease had been characterized by severe coughing that can last up to six weeks and in some countries lasting nearly 100 days.<ref name=Carbonetti>PMID: 17418639</ref>It has been documented in some cases that PT can cause [http://en.wikipedia.org/wiki/Subconjunctival_hemorrhage subconjunctival hemorrhages], [http://en.wikipedia.org/wiki/Rib_fracture rib fractures], [http://en.wikipedia.org/wiki/Hernias hernias], fainting and [http://en.wikipedia.org/wiki/Vertebral_artery_dissection vertebral artery dissection].<ref name=cornia>PMID: 20736473</ref>

As of 2010, the worldwide incidence of whooping cough has been estimated to 48.5 million cases and nearly 295,000 deaths per year.<ref name=Bettiol>PMID: 20091541</ref> With that in mind, whooping cough can affect people of any age; however, before vaccines were available the disease was most common in infants and young children but now children are immunized and the high percentage of cases are seen among adolescents.

==Introduction==

'''Pertussis Toxins''' (PT) is a protein-based exotoxin and major virulence factor produced by the bacterium [http://en.wikipedia.org/wiki/Bordetella_pertussis ''Bordetella pertussis''].<ref name=Hazes>PMID: 8637000</ref> PT causes [http://en.wikipedia.org/wiki/Whooping_cough pertussis], which is also known at [http://www.youtube.com/watch?v=1PajbAKd8Kg whooping cough] and is highly contagious bacterial disease. The disease is caused by the bacterium colonizing the respiratory tract where it then establishes an infection.<ref name=Carbonetti>PMID: 14573656</ref> This disease had been characterized by severe coughing that can last up to six weeks and in some countries lasting nearly 100 days.<ref name=Carbonetti>PMID: 17418639</ref>It has been documented in some cases that PT can cause [http://en.wikipedia.org/wiki/Subconjunctival_hemorrhage subconjunctival hemorrhages], [http://en.wikipedia.org/wiki/Rib_fracture rib fractures], [http://en.wikipedia.org/wiki/Hernias hernias], fainting and [http://en.wikipedia.org/wiki/Vertebral_artery_dissection vertebral artery dissection].<ref name=cornia>PMID: 20736473</ref>

As of 2010, the worldwide incidence of whooping cough has been estimated to 48.5 million cases and nearly 295,000 deaths per year.<ref name=Bettiol>PMID: 20091541</ref> With that in mind, whooping cough can affect people of any age; however, before vaccines were available the disease was most common in infants and young children but now children are immunized and the high percentage of cases are seen among adolescents.

==Introduction==

'''Pertussis Toxins''' (PT) is a protein-based exotoxin and major virulence factor produced by the bacterium [http://en.wikipedia.org/wiki/Bordetella_pertussis ''Bordetella pertussis''].<ref name=Hazes>PMID: 8637000</ref> PT causes [http://en.wikipedia.org/wiki/Whooping_cough pertussis], which is also known at [http://www.youtube.com/watch?v=1PajbAKd8Kg whooping cough] and is highly contagious bacterial disease. The disease is caused by the bacterium colonizing the respiratory tract where it then establishes an infection.<ref name=Carbonetti>PMID: 14573656</ref> This disease had been characterized by severe coughing that can last up to six weeks and in some countries lasting nearly 100 days.<ref name=Carbonetti>PMID: 17418639</ref>It has been documented in some cases that PT can cause [http://en.wikipedia.org/wiki/Subconjunctival_hemorrhage subconjunctival hemorrhages], [http://en.wikipedia.org/wiki/Rib_fracture rib fractures], [http://en.wikipedia.org/wiki/Hernias hernias], fainting and [http://en.wikipedia.org/wiki/Vertebral_artery_dissection vertebral artery dissection].<ref name=cornia>PMID: 20736473</ref>

As of 2010, the worldwide incidence of whooping cough has been estimated to 48.5 million cases and nearly 295,000 deaths per year.<ref name=Bettiol>PMID: 20091541</ref> With that in mind, whooping cough can affect people of any age; however, before vaccines were available the disease was most common in infants and young children but now children are immunized and the high percentage of cases are seen among adolescents.