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*'''Aromatase Excess Syndrome'''
*'''Aromatase Excess Syndrome'''
Research shows a rare disorder caused by excessive aromatase activity that can cause familial gynecomastia and feminization of both sexes. This can be inherited by an autosomal dominant manner, affected females and males differently. Females with this disorder showed signs of isosexual precocity and/or macromastia. Males showed characteristics of heterosexual precocity and/or gynecomastia. <ref> Stratakis, C., Vottero, A. "The Aromatase Excess Syndrome is Associated with Feminization of Bost Sexes and Autosomal Dominant Transmission of Aberrant p450 Aromatase Gene Transcription. [http://www.ncbi.nlm.nih.gov/pubmed/9543166] <ref/>
Research shows a rare disorder caused by excessive aromatase activity that can cause familial gynecomastia and feminization of both sexes. This can be inherited by an autosomal dominant manner, affected females and males differently. Females with this disorder showed signs of isosexual precocity and/or macromastia. Males showed characteristics of heterosexual precocity and/or gynecomastia. <ref> Stratakis, C., Vottero, A. "The Aromatase Excess Syndrome is Associated with Feminization of Bost Sexes and Autosomal Dominant Transmission of Aberrant p450 Aromatase Gene Transcription. [http://www.ncbi.nlm.nih.gov/pubmed/9543166] <ref/>
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== References ==
== References ==
<references/>
<references/>

Revision as of 18:18, 28 November 2011

This Sandbox is Reserved from September 14, 2021, through May 31, 2022, for use in the class Introduction to Biochemistry taught by User:John Means at the University of Rio Grande, Rio Grande, OH, USA. This reservation includes 5 reserved sandboxes (Sandbox Reserved 1590 through Sandbox Reserved 1594).
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Contents

Aromatase

Crystal structure of human placental aromatase cytochrome P450 in complex with androstenedione (PDB entry [1])

Drag the structure with the mouse to rotate

Introduction

Aromatase belongs to the cytochrome p450 family. During aromatization reactions, Aromatase forms an electron-transfer complex with its partner, NADPH-cytochrome p450 reductase. Aromatase is an enzyme that aids in the biosynthesis of estrogens. The aromatase enzyme can be found in many tissues in the body such as the brain, placenta, adipose tissue, blood vessels, gonads, endometrium, skin, and bone.

Function

This enzyme helps produce this female sex hromone that helps to fuel the growth of hormone receptor-positive breast cancer.

Aromatase Inhibitors

Inhibitors of Aromatase stop the estrogen production in post-menopausal women. This action is done by blocking the Aromatase enzyme by turning the hormone, androgen, into small amounts of estrogen. [1]

  • Aromatase Excess Syndrome

Research shows a rare disorder caused by excessive aromatase activity that can cause familial gynecomastia and feminization of both sexes. This can be inherited by an autosomal dominant manner, affected females and males differently. Females with this disorder showed signs of isosexual precocity and/or macromastia. Males showed characteristics of heterosexual precocity and/or gynecomastia. [2]

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