2bt0
From Proteopedia
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==Overview== | ==Overview== | ||
| - | The crystal structure of a previously reported screening hit 1 (CCT018159) | + | The crystal structure of a previously reported screening hit 1 (CCT018159) bound to the N terminal domain of molecular chaperone Hsp90 has been used to design 5-amide analogues. These exhibit enhanced potency against the target in binding and functional assays with accompanying appropriate cellular pharmacodynamic changes. Compound 11 (VER-49009) compares favorably with the clinically evaluated 17-AAG. |
==About this Structure== | ==About this Structure== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Barril, X.]] | [[Category: Barril, X.]] | ||
| - | [[Category: Brough, P | + | [[Category: Brough, P A.]] |
| - | [[Category: Cansfield, J | + | [[Category: Cansfield, J E.]] |
| - | [[Category: Drysdale, M | + | [[Category: Drysdale, M J.]] |
| - | [[Category: Dymock, B | + | [[Category: Dymock, B W.]] |
| - | [[Category: Hubbard, R | + | [[Category: Hubbard, R E.]] |
[[Category: Massey, A.]] | [[Category: Massey, A.]] | ||
[[Category: Mcdonald, E.]] | [[Category: Mcdonald, E.]] | ||
| - | [[Category: Roughley, S | + | [[Category: Roughley, S D.]] |
[[Category: Surgenor, A.]] | [[Category: Surgenor, A.]] | ||
[[Category: Webb, P.]] | [[Category: Webb, P.]] | ||
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[[Category: phosphorylation]] | [[Category: phosphorylation]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:41:19 2008'' |
Revision as of 14:41, 21 February 2008
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NOVEL, POTENT SMALL MOLECULE INHIBITORS OF THE MOLECULAR CHAPERONE HSP90 DISCOVERED THROUGH STRUCTURE-BASED DESIGN
Overview
The crystal structure of a previously reported screening hit 1 (CCT018159) bound to the N terminal domain of molecular chaperone Hsp90 has been used to design 5-amide analogues. These exhibit enhanced potency against the target in binding and functional assays with accompanying appropriate cellular pharmacodynamic changes. Compound 11 (VER-49009) compares favorably with the clinically evaluated 17-AAG.
About this Structure
2BT0 is a Single protein structure of sequence from Homo sapiens with as ligand. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Novel, potent small-molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design., Dymock BW, Barril X, Brough PA, Cansfield JE, Massey A, McDonald E, Hubbard RE, Surgenor A, Roughley SD, Webb P, Workman P, Wright L, Drysdale MJ, J Med Chem. 2005 Jun 30;48(13):4212-5. PMID:15974572
Page seeded by OCA on Thu Feb 21 16:41:19 2008
