2bt4
From Proteopedia
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==Overview== | ==Overview== | ||
| - | Selective inhibitors of type II dehydroquinase were rationally designed to | + | Selective inhibitors of type II dehydroquinase were rationally designed to explore a second binding-pocket in the active-site. The molecular modelling, synthesis, inhibition studies and crystal structure determination are described. |
==About this Structure== | ==About this Structure== | ||
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[[Category: Streptomyces coelicolor]] | [[Category: Streptomyces coelicolor]] | ||
[[Category: Abell, C.]] | [[Category: Abell, C.]] | ||
| - | [[Category: Coggins, J | + | [[Category: Coggins, J R.]] |
| - | [[Category: Lapthorn, A | + | [[Category: Lapthorn, A J.]] |
| - | [[Category: Stewart, K | + | [[Category: Stewart, K A.]] |
| - | [[Category: Toscano, M | + | [[Category: Toscano, M D.]] |
[[Category: CA2]] | [[Category: CA2]] | ||
[[Category: GOL]] | [[Category: GOL]] | ||
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[[Category: shikimate pathway]] | [[Category: shikimate pathway]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:41:21 2008'' |
Revision as of 14:41, 21 February 2008
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TYPE II DEHYDROQUINASE INHIBITOR COMPLEX
Overview
Selective inhibitors of type II dehydroquinase were rationally designed to explore a second binding-pocket in the active-site. The molecular modelling, synthesis, inhibition studies and crystal structure determination are described.
About this Structure
2BT4 is a Single protein structure of sequence from Streptomyces coelicolor with , , and as ligands. Active as 3-dehydroquinate dehydratase, with EC number 4.2.1.10 Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Rational design of new bifunctional inhibitors of type II dehydroquinase., Toscano MD, Stewart KA, Coggins JR, Lapthorn AJ, Abell C, Org Biomol Chem. 2005 Sep 7;3(17):3102-4. Epub 2005 Aug 1. PMID:16106291
Page seeded by OCA on Thu Feb 21 16:41:21 2008
Categories: 3-dehydroquinate dehydratase | Single protein | Streptomyces coelicolor | Abell, C. | Coggins, J R. | Lapthorn, A J. | Stewart, K A. | Toscano, M D. | CA2 | GOL | PO4 | TRS | Amino-acid biosynthesis | Aromatic amino acid biosynthesis | Dehydroquinase | Dehydroquinate | Drug design | Lyase | Shikimate pathway
