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1pkw
From Proteopedia
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{{STRUCTURE_1pkw| PDB=1pkw | SCENE= }} | {{STRUCTURE_1pkw| PDB=1pkw | SCENE= }} | ||
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===Crystal structure of human glutathione transferase (GST) A1-1 in complex with glutathione=== | ===Crystal structure of human glutathione transferase (GST) A1-1 in complex with glutathione=== | ||
| + | {{ABSTRACT_PUBMED_16421451}} | ||
| - | + | ==Function== | |
| - | + | [[http://www.uniprot.org/uniprot/GSTA1_HUMAN GSTA1_HUMAN]] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.<ref>PMID:20606271</ref> | |
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==About this Structure== | ==About this Structure== | ||
[[1pkw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PKW OCA]. | [[1pkw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PKW OCA]. | ||
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| + | ==See Also== | ||
| + | *[[Glutathione S-transferase|Glutathione S-transferase]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:016421451</ref><references group="xtra"/> | + | <ref group="xtra">PMID:016421451</ref><references group="xtra"/><references/> |
[[Category: Glutathione transferase]] | [[Category: Glutathione transferase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
Revision as of 10:30, 16 April 2014
Contents |
Crystal structure of human glutathione transferase (GST) A1-1 in complex with glutathione
Template:ABSTRACT PUBMED 16421451
Function
[GSTA1_HUMAN] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.[1]
About this Structure
1pkw is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Grahn E, Novotny M, Jakobsson E, Gustafsson A, Grehn L, Olin B, Madsen D, Wahlberg M, Mannervik B, Kleywegt GJ. New crystal structures of human glutathione transferase A1-1 shed light on glutathione binding and the conformation of the C-terminal helix. Acta Crystallogr D Biol Crystallogr. 2006 Feb;62(Pt 2):197-207. Epub 2006, Jan 18. PMID:16421451 doi:10.1107/S0907444905039296
- ↑ Achilonu I, Gildenhuys S, Fisher L, Burke J, Fanucchi S, Sewell BT, Fernandes M, Dirr HW. The role of a topologically conserved isoleucine in glutathione transferase structure, stability and function. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Jul 1;66(Pt, 7):776-80. Epub 2010 Jun 23. PMID:20606271 doi:10.1107/S1744309110019135
