2c0t
From Proteopedia
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==Overview== | ==Overview== | ||
| - | We describe the identification, SAR, and pharmacology of the src-family | + | We describe the identification, SAR, and pharmacology of the src-family selective lck inhibitor A-770041 that prolongs the survival of major histocompatibility mismatched allografts in models of solid organ transplant rejection for greater than 65 days. |
==About this Structure== | ==About this Structure== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Transferred entry: 2 | + | [[Category: Transferred entry: 2 7.10 1 and 2 7.10 2]] |
| - | [[Category: Borhani, D | + | [[Category: Borhani, D W.]] |
[[Category: Burchat, A.]] | [[Category: Burchat, A.]] | ||
| - | [[Category: Calderwood, D | + | [[Category: Calderwood, D J.]] |
| - | [[Category: Hirst, G | + | [[Category: Hirst, G C.]] |
[[Category: Li, B.]] | [[Category: Li, B.]] | ||
[[Category: Loew, A.]] | [[Category: Loew, A.]] | ||
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[[Category: tyrosine-protein kinase]] | [[Category: tyrosine-protein kinase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:43:39 2008'' |
Revision as of 14:43, 21 February 2008
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SRC FAMILY KINASE HCK WITH BOUND INHIBITOR A-641359
Overview
We describe the identification, SAR, and pharmacology of the src-family selective lck inhibitor A-770041 that prolongs the survival of major histocompatibility mismatched allografts in models of solid organ transplant rejection for greater than 65 days.
About this Structure
2C0T is a Single protein structure of sequence from Homo sapiens with and as ligands. Active as Transferred entry: 2.7.10.1 and 2.7.10.2, with EC number 2.7.1.112 Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Discovery of A-770041, a src-family selective orally active lck inhibitor that prevents organ allograft rejection., Burchat A, Borhani DW, Calderwood DJ, Hirst GC, Li B, Stachlewitz RF, Bioorg Med Chem Lett. 2006 Jan 1;16(1):118-22. Epub 2005 Oct 10. PMID:16216497
Page seeded by OCA on Thu Feb 21 16:43:39 2008
Categories: Homo sapiens | Single protein | Transferred entry: 2 7.10 1 and 2 7.10 2 | Borhani, D W. | Burchat, A. | Calderwood, D J. | Hirst, G C. | Li, B. | Loew, A. | CA | L3G | Alternative initiation | Atp-binding | Kinase | Lipoprotein | Myristate | Nucleotide-binding | Palmitate | Phosphorylation | Sh2 domain | Sh3 domain | Transferase | Tyrosine-protein kinase
